Dibenzo[b,f]oxepine Molecules Used in Biological Systems and Medicine

被引：10
作者：
Krawczyk, Hanna [1 ]
机构：
[1] Warsaw Univ Technol, Fac Chem, Dept Organ Chem, Noakowskiego 3, PL-00664 Warsaw, Poland
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 15期
关键词：
dibenzo[b; f]oxepine derivatives; synthesis; biological data; medical data; ANTIINFLAMMATORY CONSTITUENTS; BAUHINIA-ACURUANA; EXCITED-STATE; DERIVATIVES; ALKALOIDS; ARTOCARPOL; BINDING; ANTIMYCOBACTERIAL; DIBENZOXEPINES; IDENTIFICATION;
D O I：
10.3390/ijms241512066
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this short review, including 113 references, issues related to dibenzo[b,f]oxepine derivatives are presented. Dibenzo[b,f]oxepine scaffold is an important framework in medicinal chemistry, and its derivatives occur in several medicinally relevant plants. At the same time, the structure, production, and therapeutic effects of dibenzo[b,f]oxepines have not been extensively discussed thus far and are presented in this review. This manuscript addresses the following issues: extracting dibenzo[b,f]oxepines from plants and its significance in medicine, the biosynthesis of dibenzo[b,f]oxepines, the active synthetic dibenzo[b,f]oxepine derivatives, the potential of dibenzo[b,f]oxepines as microtubule inhibitors, and perspective for applications of dibenzo[b,f]oxepine derivatives. In conclusion, this review describes studies on various structural features and pharmacological actions of dibenzo[b,f]oxepine derivatives.
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页数：21
相关论文
共 116 条
[1]   TRICYCLIC TRIARYLETHYLENE ANTI-ESTROGENS - DIBENZ[B,F]OXEPINS, DIBENZO[B,F]THIEPINS, DIBENZO[A,E]CYCLOOCTENES, AND DIBENZO[B,F]THIOCINS [J].
ACTON, D ;
HILL, G ;
TAIT, BS .
JOURNAL OF MEDICINAL CHEMISTRY, 1983, 26 (08) :1131-1137
[2]   NUCLEAR HYDROXYLATED METABOLITE OF FLURADOLINE (2-FLUORO-11-[(BETA-METHYLAMINO)ETHYLTHIO]DIBENZ[B,F]OXEPIN HYDROCHLORIDE) - IDENTIFICATION AND SYNTHESIS [J].
AGNEW, MN ;
RIZWANIUK, A ;
ONG, HH ;
WICHMANN, JK .
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1986, 23 (01) :265-269
[3]   PACHARIN - A NEW DIBENZO(2,3-6,7)OXEPIN DERIVATIVE FROM BAUHINIA-RACEMOSA LAMK [J].
ANJANEYULU, ASR ;
REDDY, AVR ;
REDDY, DSK ;
WARD, RS ;
ADHIKESAVALU, D ;
CAMERON, TS .
TETRAHEDRON, 1984, 40 (21) :4245-4252
[4]  
[Anonymous], 2017, CONG MUSC DYSTR ASC
[5]   Synthesis of targeted dibenzo[b,f]thiepines and dibenzo[b,f]oxepines as potential lead molecules with promising anti-breast cancer activity [J].
Ansari, Mohd. Imran ;
Hussain, Mohd. Kamil ;
Arun, Ashutosh ;
Chakravarti, Bandana ;
Konwar, Rituraj ;
Hajela, K. .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 99 :113-124
[6]   Novel 2-N,N dimethylaminomethyl-2,3,3a,12b-tetrahydrodibenzo[b,f]furo]2,3-d]oxepin derivatives displaying combined norepinephrine reuptake inhibition and 5-HT2A/2c receptor antagonism [J].
Bartolomé, JM ;
Alcudia, A ;
Andrés, JI ;
Cid, JM ;
García, M ;
Megens, A ;
Toledo, MA ;
Trabanco, AA .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (11) :2898-2901
[7]  
Belenki L.I., 2008, COMPREHENSIVE HETERO, VVolume 13, P45
[8]   BETA-PHENYLETHYLAMINES AND THE ISOQUINOLINE ALKALOIDS [J].
BENTLEY, KW .
NATURAL PRODUCT REPORTS, 1989, 6 (04) :405-432
[9]   An Efficient Synthesis of Dibenzo[b,f]oxepins by Ring-Closing Metathesis [J].
Bharath, Yada ;
Thirupathi, Barla ;
Ranjit, Gurram ;
Mohapatra, Debendra K. .
ASIAN JOURNAL OF ORGANIC CHEMISTRY, 2013, 2 (10) :848-851
[10]   SECOCULARINES - A NEW GROUP OF ISOQUINOLINE RELATED ALKALOIDS PRESENT IN THE FUMARIACEAE [J].
BOENTE, JM ;
CASTEDO, L ;
DOMINGUEZ, D ;
FARINA, A ;
DELERA, AR ;
VILLAVERDE, MC .
TETRAHEDRON LETTERS, 1984, 25 (08) :889-892
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