Pituitary Diseases and COVID-19 Outcomes in South Korea: A Nationwide Cohort Study

被引:0
作者
Ha, Jeonghoon [1 ]
Kim, Kyoung Min [2 ]
Lim, Dong-Jun [1 ]
Song, Keeho [3 ]
Seo, Gi Hyeon [4 ]
机构
[1] Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Internal Med,Div Endocrinol & Metab, Seoul 06591, South Korea
[2] Yonsei Univ, Yongin Severance Hosp, Dept Internal Med, Div Endocrinol,Coll Med, Yongin 16995, South Korea
[3] Konkuk Univ, Dept Internal Med, Div Endocrinol & Metab, Sch Med, Seoul 05030, South Korea
[4] Hlth Insurance Review & Assessment Serv, Wonju 26465, South Korea
关键词
COVID-19; pituitary disease; mortality; CLINICAL CHARACTERISTICS; ADRENAL INSUFFICIENCY; STATEMENT; ENDOCRINE; RISK;
D O I
10.3390/jcm12144799
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The pituitary gland is either directly or indirectly impacted by SARS-CoV-2 infection. As a consequence of SARS-CoV-2 infection, hypothalamic-pituitary dysfunction or pituitary apoplexy can occur. This study aimed to investigate severe COVID-19 outcomes and COVID-19-related mortality in patients with underlying pituitary disease in Korea using a nationwide cohort database. The data required for this study were obtained from the Health Insurance Review and Assessment Service of Korea. Patients with SARS-CoV-2 infection between January 2020 and December 2021 were divided into the following three groups and analyzed: Group A, those who were hospitalized for SARS-CoV-2 infection without underlying pituitary disease (n = 725,170); Group B, those who were hospitalized for SARS-CoV-2 infection with underlying pituitary disease without exposure to systemic steroids (n = 1509); and Group C, patients with underlying pituitary disease and exposure to systemic steroids (n = 365). Differences in severe COVID-19, requirement for oxygen therapy, intensive care unit admission, application of invasive ventilation or use of extracorporeal membrane oxygenation, and COVID-19-related deaths between groups were then analyzed. Group C had the highest rates of hospitalization after COVID-19 infection (82.2%) and mortality within 30 days of infection (6.8%). Group B had a 1.3-fold increase in severe COVID-19 outcomes compared to Group A. Group C had 1.8-fold and 1.3-fold increases in severe COVID-19 outcomes compared to Group A and Group B, respectively. Group C also had 2.34 and 3.24 times higher mortality rates within 30 days of COVID-19 infection than Group A and Group B, respectively. In conclusion, patients with pituitary disease who are receiving systemic steroids have poorer outcomes and higher mortality associated with COVID-19. Therefore, thorough COVID-19 infection control is required in these patients.
引用
收藏
页数:10
相关论文
共 42 条
[1]   COVID-19 risk and outcomes in adult asthmatic patients treated with biologics or systemic corticosteroids: Nationwide real-world evidence [J].
Adir, Yochai ;
Humbert, Marc ;
Saliba, Walid .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2021, 148 (02) :361-+
[2]   ENDOCRINOLOGY IN THE TIME OF COVID-19 Management of adrenal insufficiency [J].
Arlt, Wiebke ;
Baldeweg, Stephanie E. ;
Pearce, Simon H. S. ;
Simpson, Helen L. .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2020, 183 (01) :G25-G32
[3]   Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 Replication in an Immunocompromised Patient [J].
Baang, Ji Hoon ;
Smith, Christopher ;
Mirabelli, Carmen ;
Valesano, Andrew L. ;
Manthei, David M. ;
Bachman, Michael A. ;
Wobus, Christiane E. ;
Adams, Michael ;
Washer, Laraine ;
Martin, Emily T. ;
Lauring, Adam S. .
JOURNAL OF INFECTIOUS DISEASES, 2021, 223 (01) :23-27
[4]   Primary adrenal insufficiency is associated with impaired natural killer cell function: a potential link to increased mortality [J].
Bancos, Irina ;
Hazeldine, Jon ;
Chortis, Vasileios ;
Hampson, Peter ;
Taylor, Angela E. ;
Lord, Janet M. ;
Arlt, Wiebke .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2017, 176 (04) :471-480
[5]   Hyponatremia, IL-6, and SARS-CoV-2 (COVID-19) infection: may all fit together? [J].
Berni, A. ;
Malandrino, D. ;
Parenti, G. ;
Maggi, M. ;
Poggesi, L. ;
Peri, A. .
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2020, 43 (08) :1137-1139
[6]   Clinical characteristics of patients hospitalized with COVID-19 in Spain: Results from the SEMI-COVID-19 Registry [J].
Casas-Rojo, J. M. ;
Anton-Santos, J. M. ;
Millan-Nunez-Cortes, J. ;
Lumbreras-Bermejo, C. ;
Ramos-Rincon, J. M. ;
Roy-Vallejo, E. ;
Artero-Mora, A. ;
Arnalich-Fernandez, F. ;
Garcia-Brunen, J. M. ;
Vargas-Nunez, J. A. ;
Freire-Castro, Sj ;
Manzano-Espinosa, L. ;
Perales-Fraile, I ;
Crestelo-Vieitez, A. ;
Puchades-Gimeno, F. ;
Rodilla-Sala, E. ;
Solis-Marquinez, M. N. ;
Bonet-Tur, D. ;
Fidalgo-Moreno, M. P. ;
Fonseca-Aizpuru, E. M. ;
Carrasco-Sanchez, F. J. ;
Rabadan-Pejenaute, E. ;
Rubio-Rivas, M. ;
Torres-Pena, J. D. ;
Gomez-Huelgas, R. .
REVISTA CLINICA ESPANOLA, 2020, 220 (08) :480-494
[7]   Pituitary apoplexy associated with acute COVID-19 infection and pregnancy [J].
Chan, Julie L. ;
Gregory, Kimberly D. ;
Smithson, Sarah S. ;
Naqvi, Mariam ;
Mamelak, Adam N. .
PITUITARY, 2020, 23 (06) :716-720
[8]   Big Data Research in the Field of Endocrine Diseases Using the Korean National Health Information Database [J].
Cho, Sun Wook ;
Kim, Jung Hee ;
Choi, Han Seok ;
Ahn, Hwa Young ;
Kim, Mee Kyoung ;
Rhee, Eun Jung .
ENDOCRINOLOGY AND METABOLISM, 2023, 38 (01) :10-24
[9]   Risk for Newly Diagnosed Type 2 Diabetes Mellitus after COVID-19 among Korean Adults: A Nationwide Matched Cohort Study [J].
Choi, Jong Han ;
Kim, Kyoung Min ;
Song, Keeho ;
Seo, Gi Hyeon .
ENDOCRINOLOGY AND METABOLISM, 2023, 38 (02) :245-252
[10]   Hyperglycemia at Hospital Admission Is Associated With Severity of the Prognosis in Patients Hospitalized for COVID-19: The Pisa COVID-19 Study [J].
Coppelli, Alberto ;
Giannarelli, Rosa ;
Aragona, Michele ;
Penno, Giuseppe ;
Falcone, Marco ;
Tiseo, Giusy ;
Ghiadoni, Lorenzo ;
Barbieri, Greta ;
Monzani, Fabio ;
Virdis, Agostino ;
Menichetti, Francesco ;
Del Prato, Stefano .
DIABETES CARE, 2020, 43 (10) :2345-2348