Identification of Key Genes Involved in Glioblastoma by Integrated Bioinformatics Analysis

被引：0
作者：
Yan, Dongke [1 ]
Gong, Yanchao [2 ]
Wang, Yongling [3 ]
Li, Longmei [1 ]
Tong, Wenhui [1 ]
Pang, Jingjie [4 ]
机构：
[1] Tianjin Vocat Inst, Coll Biol & Environm Engn, Tianjin 300410, Peoples R China
[2] Coll Environm & Chem Engn, Tianjin Bohai Vocat Technol Coll, Tianjin 300402, Peoples R China
[3] Tianjin Ocean Pal Carol Biotech Co Ltd, Tianjin 300350, Peoples R China
[4] Henan Aojie Biotech Co Ltd, Juqiao 450002, Henan, Peoples R China
来源：
JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING | 2023年 / 13卷 / 02期
关键词：
Key Genes; Glioblastoma; Immune Cells Infiltration; Overall Survival; APOPTOSIS; PROLIFERATION; MICAL2;
D O I：
10.1166/jbt.2023.3251
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Glioblastoma (GBM) is the most frequently identified malignancy of the brain. Due to the special tumor location, it is extremely urgent to explore key genes involved in the pathogenesis of GBM. In this study, we tried to identify vital genes that participate in the GBM progression by analyz-ing TCGA-sourced transcriptome data and identified 3183 differentially expressed genes (DEGs). Meanwhile, we also observed that CRYGN, MICAL2, BICDL1, PLK2, MTHFD2, OSMR, COL22A1, MSTN, and G0S2 expressions were significantly associated with patients' survival. Immune infil-tration analysis indicated that eight genes enhanced the immune infiltration in GBM, while BICDL1 had no significant effect. In conclusion, our study demonstrates that the eight genes are potential key genes involved in GBM and significantly connected to patients' prognosis.
引用
收藏
页码：231 / 240
页数：10
相关论文
共 24 条
  • [1] Decoding and targeting the molecular basis of MACC1-driven metastatic spread: Lessons from big data mining and clinical-experimental approaches
    Budczies, Jan
    Kluck, Klaus
    Walther, Wolfgang
    Stein, Ulrike
    [J]. SEMINARS IN CANCER BIOLOGY, 2020, 60 : 365 - 379
  • [2] Overexpression of MICAL2, a novel tumor-promoting factor, accelerates tumor progression through regulating cell proliferation and EMT
    Cai, Yongqiang
    Lu, Jinping
    Tang, Faqing
    [J]. JOURNAL OF CANCER, 2018, 9 (03): : 521 - 527
  • [3] A human tissue-specific transcriptomic analysis reveals a complex relationship between aging, cancer, and cellular senescence
    Chatsirisupachai, Kasit
    Palmer, Daniel
    Ferreira, Susana
    de Magalhaes, Joao Pedro
    [J]. AGING CELL, 2019, 18 (06)
  • [4] Heterogeneous nuclear ribonucleoprotein K is associated with poor prognosis and regulates proliferation and apoptosis in bladder cancer
    Chen, Xu
    Gu, Peng
    Xie, Ruihui
    Han, Jinli
    Liu, Hao
    Wang, Bo
    Xie, Weibin
    Xie, Weijie
    Zhong, Guangzheng
    Chen, Changhao
    Xie, Shujie
    Jiang, Ning
    Lin, Tianxin
    Huang, Jian
    [J]. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2017, 21 (07) : 1266 - 1279
  • [5] A Pan-cancer Transcriptome Analysis Reveals Pervasive Regulation through Alternative Promoters
    Demircioglu, Deniz
    Cukuroglu, Engin
    Kindermans, Martin
    Nandi, Tannistha
    Calabrese, Claudia
    Fonseca, Nuno A.
    Kahles, Andre
    Kjong-Van Lehmann
    Stegle, Oliver
    Brazma, Alvis
    Brooks, Angela N.
    Ratsch, Gunnar
    Tan, Patrick
    Goke, Jonathan
    [J]. CELL, 2019, 178 (06) : 1465 - +
  • [6] Methylation dependent down-regulation of G0S2 leads to suppression of invasion and improved prognosis of IDH1-mutant glioma
    Fukunaga, Takanori
    Fujita, Yuki
    Kishima, Haruhiko
    Yamashita, Toshihide
    [J]. PLOS ONE, 2018, 13 (11):
  • [7] Myostatin Gene Inactivation Prevents Skeletal Muscle Wasting in Cancer
    Gallot, Yann S.
    Durieux, Anne-Cecile
    Castells, Josiane
    Desgeorges, Marine M.
    Vernus, Barbara
    Plantureux, Lea
    Remond, Didier
    Jahnke, Vanessa E.
    Lefai, Etienne
    Dardevet, Dominique
    Nemoz, Georges
    Schaeffer, Laurent
    Bonnieu, Anne
    Freyssenet, Damien G.
    [J]. CANCER RESEARCH, 2014, 74 (24) : 7344 - 7356
  • [8] MTHFD2 links RNA methylation to metabolic reprogramming in renal cell carcinoma
    Green, Nathanael H.
    Galvan, Daniel L.
    Badal, Shawn S.
    Chang, Benny H.
    LeBleu, Valerie S.
    Long, Jianyin
    Jonasch, Eric
    Danesh, Farhad R.
    [J]. ONCOGENE, 2019, 38 (34) : 6211 - 6225
  • [9] Functional Role of γ-Crystallin N in the Auditory Hindbrain
    Hartwich, Heiner
    Rosengauer, Elena
    Ruettiger, Lukas
    Wilms, Viviane
    Waterholter, Sarah-Kristin
    Nothwang, Hans Gerd
    [J]. PLOS ONE, 2016, 11 (08):
  • [10] Jahani-Asl A., 2016, Nature neuroscience
123