Towards the use of an amino acid cleavable linker for solid-phase chemical synthesis of peptides and proteins

被引：5

作者：

Cardella, Davide ^{[1
]}

Tsai, Yu-Hsuan ^{[2
]}

Luk, Louis Y. P. ^{[1
]}

机构：

[1] Cardiff Univ, Sch Chem, Cardiff CF103AT, England

[2] Inst Mol Physiol, Shenzhen Bay Lab, Shenzhen 518132, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2023年 / 21卷 / 05期

关键词：

LIGATION;

D O I：

10.1039/d2ob02198f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of proteins by solid-phase chemical ligation (SPCL) suffers from the paucity of linkers that can be cleaved under mild conditions. Here, we deployed a spontaneous nickel-assisted cleavage (SNAC) tag, known to undergo spontaneous cleavage in the presence of nickel(ii), as a linker for C-to-N SPCL.

引用

页码：966 / 969

页数：4

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