Spreading of alpha-synuclein between different cell types

被引：9
|
作者：
Ruf, Wolfgang P. [1 ]
Meirelles, Joao L. [2 ]
Danzer, Karin M. [1 ,2 ,3 ]
机构：
[1] Univ Ulm, Univ Clin, Dept Neurol, Ulm, Germany
[2] German Ctr Neurodegenerat Dis DZNE, Ulm, Germany
[3] Albert Einstein Allee 11, D-89081 Ulm, Germany
来源：
BEHAVIOURAL BRAIN RESEARCH | 2023年 / 436卷
关键词：
PARKINSONS-DISEASE; ACTIVATES MICROGLIA; CLEARANCE; PROTEIN; RECEPTOR; NEURONS; NEURODEGENERATION; PHOSPHORYLATION; PROPAGATION; EXOCYTOSIS;
D O I：
10.1016/j.bbr.2022.114059
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Aggregation of alpha-synuclein (alpha-syn) is central in Parkinson's disease as well as in other synucleinopathies. Recent evidence suggests that not only intracellular aggregation of alpha-syn plays an important role for disease pathogenesis but also cell-to-cell propagation of alpha-syn seems to significantly contribute to pathological changes in synucleinopathies. In this mini-review we summarize current aspects of spreading of alpha-syn between brain cell types and its role in pathology.
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页数：5
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