A dual-site multifunctional fluorescent probe for selective detection of endogenous H2O2 and SO2 derivatives based on ICT process and its bioimaging application

被引：13

作者：

Liu, Xue-Liang ^{[1
]}

Yan, Mengdi ^{[2
]}

Chen, Zhi-guo ^{[1
]}

Zhang, Bingxin ^{[2
]}

Yao, Ningcong ^{[1
]}

Zhao, Shan ^{[1
]}

Zhao, Xiaoxia ^{[1
]}

Zhang, Tao ^{[2
]}

Hai, Guangfan ^{[2
]}

机构：

[1] Xinxiang Med Univ, Sch Basic Med Sci, Jinsui Rd 601, Xinxiang 453003, Henan, Peoples R China

[2] Xinxiang Med Univ, Sch Pharm, Jinsui Rd 601, Xinxiang 453003, Henan, Peoples R China

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2023年 / 286卷

关键词：

Fluorescent probe; Dual; -site; Hydrogen peroxide; SO; 2; derivatives; Imaging; HYDROGEN-PEROXIDE; OXIDATIVE STRESS; LIVING CELLS; RATIOMETRIC DETECTION; NANOPARTICLES; MITOCHONDRIA; 2-PHOTON; CYSTEINE; COMPLEX; MODELS;

D O I：

10.1016/j.saa.2022.121955

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

In this paper, we reported a coumarin-based fluorescent probe for selective detection of H2O2/SO2 derivatives via ICT process. To the best of our knowledge, it was few reported with the same probe to enable visual detection of H2O2/SO2 derivatives in vivo and in vitro. H2O2 and SO32- were selectively sensed over other analytes, and the probe displayed 20-fold and 220-fold relative fluorescence intensity respectively, as well as the good linear relationship and the excellent detection limits of 2.7 * 103 nM and 19.3 nM. Furthermore, the probe was successfully used for fluorescence imaging of the HeLa cells and the mice to monitor exogenous and endogenous H2O2 and SO32-, suggesting its potential biomedical application for investigation and detection the intermediate indicator of oxidative stress in vitro and in vivo.

引用

页数：9

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