[1] Univ Edinburgh, Usher Inst, Old Med Sch,Teviot Pl, Edinburgh EH8 9AG, Scotland
[2] Univ Edinburgh, Inst Study Sci Technol & Innovat, Edinburgh, Scotland
[3] Royal Infirm Hosp, Dept Radiol, Edinburgh, Scotland
[4] Univ Edinburgh, Bayes Ctr, Edinburgh, Scotland
[5] Univ Edinburgh, Ctr Cardiovasc Sci, Edinburgh Imaging & Neurosci, Edinburgh, Scotland