Serum tryptophan metabolites are associated with erosive hand osteoarthritis and pain: results from the DIGICOD cohort

被引：14

作者：

Binvignat, M. ^{[1
,2
,3
,4
]}

Emond, P. ^{[5
,6
]}

Mifsud, F. ^{[7
,8
]}

Miao, B. ^{[3
]}

Courties, A. ^{[1
,4
]}

Lefevre, A. ^{[5
]}

Maheu, E. ^{[1
]}

Crema, M. D. ^{[9
]}

Klatzmann, D. ^{[2
,10
,11
]}

Kloppenburg, M. ^{[12
,13
]}

Richette, P. ^{[14
]}

Butte, A. J. ^{[3
]}

Mariotti-Ferrandiz, E. ^{[2
]}

Berenbaum, F. ^{[1
,4
]}

Sokol, H. ^{[4
,15
,16
]}

Sellam, J. ^{[1
,4
]}

机构：

[1] Sorbonne Univ, St Antoine Hosp, AP HP,Dept Rheumatol, Ctr Rech St Antoine,INSERM,UMRS 938, Paris, France

[2] Sorbonne Univ, Pitie Salpetriere Hosp, Immunol Immunopathol Immunotherapy Lab I3, Inserm URMS 959, Paris, France

[3] Univ Calif San Francisco, Bakar Computat Hlth Sci Inst, San Francisco, CA USA

[4] Paris Ctr Microbiome Med PaCeMM FHU, Paris, France

[5] Univ Tours, IBrain Lab, Inserm, UMR 1253, Tours, France

[6] Ctr Hosp Univ Tours, Dept Nucl Med, Tours, France

[7] Univ Paris, BFA, CNRS UMR 8251, F-75013 Paris, France

[8] Univ Calif San Francisco, Diabet Ctr, San Francisco, CA USA

[9] French Natl Inst Sports INSEP, Inst Sports Imaging, Paris, France

[10] Assistance Publ Hop Paris AP HP, Biotherapy CIC BTi, Paris, France

[11] Assistance Publ Hop Paris AP HP, Inflammat Immunopathol Biotherapy Dept I2B, Paris, France

[12] Leiden Univ, Dept Rheumatol, Med Ctr, Leiden, Netherlands

[13] Leiden Univ, Dept Clin Epidemiol, Med Ctr, Leiden, Netherlands

[14] Univ Paris, Lariboisiere Hosp, Assistance Publ Hop Paris AP HP, Dept Rheumatol,INSERM,U1132, Paris, France

[15] Sorbonne Univ, St Antoine Hosp, AP HP,Dept Gastroenterol, Ctr Rech St Antoine,INSERM,UMRS 938, Paris, France

[16] Univ Paris Saclay, Micalis Inst, INRAE, AgroParisTech, Jouy En Josas, France

来源：

OSTEOARTHRITIS AND CARTILAGE | 2023年 / 31卷 / 08期

关键词：

Hand osteoarthritis; Erosive hand osteoarthritis; Metabolomic; Gut microbiome; Symptoms; Pain; ARTHRITIS; INFLAMMATION; STRESS;

D O I：

10.1016/j.joca.2023.04.007

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Objective: To investigate host and gut-microbiota related Tryptophan metabolism in hand osteoarthritis (HOA).Methods: The baseline serum concentration of 20 Tryptophan metabolites was measured in 416 HOA patients in a cross-sectional analysis of the DIGICOD cohort. Tryptophan metabolites levels, metabolite-ratios and metabolism pathway activation were compared between erosive (N = 141) and non-erosive HOA (N = 275) by multiple logistic regressions adjusted on age, BMI and sex. The association between Tryp-tophan metabolite levels and HOA symptoms was investigated by a Spearman's rank correlation analysis.Results: Four serum Tryptophan metabolites, eight metabolite ratios and one metabolism pathway were associated with erosive HOA. Erosive HOA was negatively associated with Tryptophan (odds ratio (OR) = 0.41, 95% confidence interval [0.24-0.70]), indole-3-aldehyde (OR = 0.67 [0.51-0.90]) and 3-OH-anthranilic acid (OR = 1.32 [1.13-1.54]) and positively with 5-OH-Tryptophan levels (OR = 1.41 [1.13-1.77]). The pro-inflammatory kynurenine-indoleamine 2,3-dioxygenase pathway was upregulated in erosive HOA (OR = 1.60 [1.11-2.29]). Eleven metabolites were correlated with HOA symptoms and were mostly pain-related. Serotonin and N-acetyl serotonin levels were negatively correlated with number of tender joints. Indole-3-aldehyde level was negatively correlated and 3-OH-anthranilic acid, 3-OH-kynurenine and 5-OH-Tryptophan levels were positively correlated with number of patients-reported painful joints. Quinolinic acid and 3-OH-kynurenine levels correlated positively with AUSCAN pain.Conclusions: Tryptophan metabolites disturbance is associated with erosive HOA and pain and empha-size the role of low-grade inflammation and gut dysbiosis in HOA.& COPY; 2023 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

引用

页码：1132 / 1143

页数：12

共 51 条

[41] The DIGICOD cohort: A hospital-based observational prospective cohort of patients with hand osteoarthritis - methodology and baseline characteristics of the population [J].