Oncological outcome of vocal cord-only radiotherapy for cT1-T2 glottic laryngeal squamous cell carcinoma

被引：7

作者：

de Ridder, Mischa ^{[1
]}

Rijken, Johannes A. ^{[2
]}

Smits, Hilde J. G. ^{[1
]}

Smid, Ernst J. ^{[1
]}

Doornaert, Patricia A. H. ^{[1
]}

de Bree, Remco ^{[2
]}

机构：

[1] Univ Med Ctr Utrecht, Dept Radiotherapy, Heidelberglaan 100,Postbox 85500, NL-3508 GA Utrecht, Netherlands

[2] Univ Med Ctr Utrecht, Dept Head & Neck Surg Oncol, Utrecht, Netherlands

来源：

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY | 2023年 / 280卷 / 07期

关键词：

Radiotherapy; Glottic cancer; Larynx; Vocal cord; VMAT; COMPUTED-TOMOGRAPHY; CANCER; DELINEATION; INTENSITY; CO2-LASER; ACCURACY; ALCOHOL; SMOKING; RISK; HEAD;

D O I：

10.1007/s00405-023-07904-2

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

PurposeEarly-stage glottic cancer can be treated with radiotherapy only. Modern radiotherapy solutions allow for individualized dose distributions, hypofractionation and sparing of organs at risk. The target volume used to be the entire voice box. This series describe the oncological outcome and toxicity of individualized vocal cord-only hypofractionated radiotherapy for early stage (cT1a-T2 N0).MethodsRetrospective cohort study with patients treated in a single center between 2014 and 2020.ResultsA total of 93 patients were included. Local control rate was 100% for cT1a, 97% for cT1b and 77% for cT2. Risk factor for local recurrence was smoking during radiotherapy. Laryngectomy-free survival was 90% at 5 years. Grade III or higher late toxicity was 3.7%.ConclusionVocal cord-only hypofractionated radiotherapy appears to be oncologically safe in early-stage glottic cancer. Modern, image-guided radiotherapy led to comparable results as historical series with very limited late toxicity.

引用

页码：3345 / 3352

页数：8

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