Carbohydrate antigen 125 in congestive heart failure: ready for clinical application?

被引：5

作者：

Feng, Rui ^{[1
,2
]}

Zhang, Zhenlu ^{[1
]}

Fan, Qingkun ^{[1
]}

机构：

[1] Wuhan Univ Sci & Technol, Dept Lab Med, Wuhan Asian Heart Hosp, Wuhan, Peoples R China

[2] Wuhan Univ Sci & Technol, Sch Med, Wuhan, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2023年 / 13卷

关键词：

carbohydrate antigen 125; congestive heart failure; heart failure; N-terminal Pro-B-type natriuretic peptide; tissue congestion; BRAIN NATRIURETIC PEPTIDE; OVARIAN-CANCER ANTIGEN; SERUM CA-125 LEVELS; TUMOR-MARKERS; INFLAMMATORY ACTIVATION; VENTRICULAR-FUNCTION; ATRIAL-FIBRILLATION; PROGNOSTIC VALUE; AORTIC-STENOSIS; RISK PREDICTION;

D O I：

10.3389/fonc.2023.1161723

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Congestion is the permanent mechanism driving disease progression in patients with acute heart failure (AHF) and also is an important treatment target. However, distinguishing between the two different phenotypes (intravascular congestion and tissue congestion) for personalized treatment remains challenging. Historically, carbohydrate antigen 125 (CA125) has been a frequently used biomarker for the screening, diagnosis, and prognosis of ovarian cancer. Interestingly, CA125 is highly sensitive to tissue congestion and shows potential for clinical monitoring and optimal treatment of congestive heart failure (HF). Furthermore, in terms of right heart function parameters, CA125 levels are more advantageous than other biomarkers of HF. CA125 is expected to become a new biological alternative marker for congestive HF and thereby is expected be widely used in clinical practice.

引用

页数：14

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