Eco-friendly, Fact and Green Synthesis of Methanobenzo[d]naphtho[1,2-g][1,3]Oxazocines using 1-Butyl-3-methylimidazolium Hydroxide under Solvent-free Ball Milling

A green, solvent-free, and efficient strategy for the assembly of methanobenzo[d]naphtho[1,2-g][1,3]oxazocine heterocycles using 1-butyl-3-methylimidazolium hydroxide ([bmim]OH) ionic liquid under ball-milling solvent-free condition has been developed. For this purpose, the synthesis of methanobenzo[d]naphtho[1,2-g][1,3]oxazocine derivatives was carried out in a single step and one-pot reaction using 2-naphthol and quinolinium salts with the catalyst, 1-butyl-3-methylimidazolium hydroxide ([bmim]OH), at room temperature. This protocol's specific advantages are environmentally benign media, high yield, easy purification and short experimental time.