Effect of nutritional status before radiotherapy on radiation-induced acute toxicities in patients with nasopharyngeal carcinoma

被引：10

作者：

Song, Xiurong ^{[1
]}

Su, Li ^{[1
,2
]}

Lin, Qiaojing ^{[1
]}

Liu, Shiping ^{[1
]}

Zhang, Weijian ^{[1
,2
]}

Hong, Jinsheng ^{[1
,2
]}

机构：

[1] Fujian Med Univ, Affiliated Hosp 1, Canc Ctr, Dept Radiotherapy, Chazhong Rd 20, Fuzhou 350005, Fujian, Peoples R China

[2] Fujian Med Univ, Affiliated Hosp 1, Key Lab Radiat Biol Fujian Higher Educ Inst, Fuzhou, Peoples R China

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2023年 / 45卷 / 03期

关键词：

intensity-modulated radiotherapy; malnutrition; nasopharyngeal carcinoma; nutritional status; radiation injury; PARAMETERS; PROGNOSIS; THERAPY;

D O I：

10.1002/hed.27275

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

BackgroundTo investigate the effect of nutritional status on radiation-induced acute toxicities in nasopharyngeal carcinoma (NPC) patients before radiotherapy. MethodsNutritional status of 228 patients with NPC who received intensity-modulated radiotherapy was retrospectively analyzed by modified nutrition index (m-NI). Cumulative grading score of six common acute toxicities were defined as total score for acute toxicities. ResultsM-NI <= 6 is a risk factor for xerostomia (p = 0.016, OR = 0.208, 95% CI 0.058-0.743), oral mucositis (p = 0.016, OR = 0.287, 95% CI 0.104-0.793), dysgeusia (p = 0.001, OR = 0.028, 95% CI 0.004-0.217), and dysphagia (p = 0.015, OR = 0.251, 95% CI 0.083-0.764) as well in patients with NPC. Total score of radiation-induced acute toxicities of patients with malnutrition (13.6 +/- 1.7) was significantly higher than that of patients with normal nutrition (12.0 +/- 2.4) (t = -5.464, p < 0.001). ConclusionsNPC patients with malnutrition before radiotherapy develop more serious dysgeusia, oral mucositis, dysphagia, and xerostomia after intensity-modulated radiotherapy.

引用

页码：620 / 628

页数：9

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