Increased artemisinin production by promoting glandular secretory trichome formation and reconstructing the artemisinin biosynthetic pathway in Artemisia annua

被引:18
作者
Li, Yongpeng [1 ,2 ]
Qin, Wei [1 ]
Liu, Hang [1 ]
Chen, Tiantian [1 ]
Yan, Xin [1 ]
He, Weizhi [1 ]
Peng, Bowen [1 ]
Shao, Jin [1 ]
Fu, Xueqing [1 ]
Li, Ling [1 ]
Hao, Xiaolong [2 ]
Kai, Guoyin [2 ]
Tang, Kexuan [1 ]
机构
[1] Shanghai Jiao Tong Univ, Frontiers Sci Ctr Transformat Mol, Fudan SJTU Nottingham Plant Biotechnol R&D Ctr, Plant Biotechnol Res Ctr,Joint Int Res Lab Metab &, Shanghai 200240, Peoples R China
[2] Zhejiang Chinese Med Univ, Acad Chinese Med Sci, Sch Pharmaceut Sci, Lab Med Plant Biotechnol, Hangzhou 310053, Peoples R China
基金
中国博士后科学基金; 中国国家自然科学基金; 比尔及梅琳达.盖茨基金会; 国家重点研发计划;
关键词
DRUG;
D O I
10.1093/hr/uhad055
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
引用
收藏
页数:3
相关论文
共 10 条
[1]   Discovery and modulation of diterpenoid metabolism improves glandular trichome formation, artemisinin production and stress resilience in Artemisia annua [J].
Chen, Ruibing ;
Bu, Yuejuan ;
Ren, Junze ;
Pelot, Kyle A. ;
Hu, Xiangyang ;
Diao, Yong ;
Chen, Wansheng ;
Zerbe, Philipp ;
Zhang, Lei .
NEW PHYTOLOGIST, 2021, 230 (06) :2387-2403
[2]   Artemisia annua mutant impaired in artemisinin synthesis demonstrates importance of nonenzymatic conversion in terpenoid metabolism [J].
Czechowski, Tomasz ;
Larson, Tony R. ;
Catania, Theresa M. ;
Harvey, David ;
Brown, Geoffrey D. ;
Graham, Ian A. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (52) :15150-15155
[3]   Generation of the potent anti-malarial drug artemisinin in tobacco [J].
Farhi, Moran ;
Marhevka, Elena ;
Ben-Ari, Julius ;
Algamas-Dimantov, Anna ;
Liang, Zhuobin ;
Zeevi, Vardit ;
Edelbaum, Orit ;
Spitzer-Rimon, Ben ;
Abeliovich, Hagai ;
Schwartz, Betty ;
Tzfira, Tzvi ;
Vainstein, Alexander .
NATURE BIOTECHNOLOGY, 2011, 29 (12) :1072-1074
[4]   Parallel Transcriptional Regulation of Artemisinin and Flavonoid Biosynthesis [J].
Hassani, Danial ;
Fu, Xueqing ;
Shen, Qian ;
Khalid, Muhammad ;
Rose, Jocelyn K. C. ;
Tang, Kexuan .
TRENDS IN PLANT SCIENCE, 2020, 25 (05) :466-476
[5]   Stable Production of the Antimalarial Drug Artemisinin in the Moss Physcomitrella patens [J].
Ikram, Nur Kusaira Binti Khairul ;
Kashkooli, Arman Beyraghdar ;
Peramuna, Anantha Vithakshana ;
van der Krol, Alexander R. ;
Bouwmeester, Harro ;
Simonsen, Henrik Toft .
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2017, 5
[6]   Increased sesqui- and triterpene production by co-expression of HMG-CoA reductase and biotin carboxyl carrier protein in tobacco (Nicotiana benthamiana) [J].
Lee, Ah-Reum ;
Kwon, Moonhyuk ;
Kang, Min-Kyoung ;
Kim, Jeonghan ;
Kim, Soo-Un ;
Ro, Dae-Kyun .
METABOLIC ENGINEERING, 2019, 52 :20-28
[7]   The truncated AaActin1 promoter is a candidate tool for metabolic engineering of artemisinin biosynthesis in Artemisia annua L. [J].
Li, Yongpeng ;
Chen, Tiantian ;
Liu, Hang ;
Qin, Wei ;
Yan, Xin ;
Wu-Zhang, Kuanyu ;
Peng, Bowen ;
Zhang, Yaojie ;
Yao, Xinghao ;
Fu, Xueqing ;
Li, Ling ;
Tang, Kexuan .
JOURNAL OF PLANT PHYSIOLOGY, 2022, 274
[8]   High-level semi-synthetic production of the potent antimalarial artemisinin [J].
Paddon, C. J. ;
Westfall, P. J. ;
Pitera, D. J. ;
Benjamin, K. ;
Fisher, K. ;
McPhee, D. ;
Leavell, M. D. ;
Tai, A. ;
Main, A. ;
Eng, D. ;
Polichuk, D. R. ;
Teoh, K. H. ;
Reed, D. W. ;
Treynor, T. ;
Lenihan, J. ;
Fleck, M. ;
Bajad, S. ;
Dang, G. ;
Dengrove, D. ;
Diola, D. ;
Dorin, G. ;
Ellens, K. W. ;
Fickes, S. ;
Galazzo, J. ;
Gaucher, S. P. ;
Geistlinger, T. ;
Henry, R. ;
Hepp, M. ;
Horning, T. ;
Iqbal, T. ;
Jiang, H. ;
Kizer, L. ;
Lieu, B. ;
Melis, D. ;
Moss, N. ;
Regentin, R. ;
Secrest, S. ;
Tsuruta, H. ;
Vazquez, R. ;
Westblade, L. F. ;
Xu, L. ;
Yu, M. ;
Zhang, Y. ;
Zhao, L. ;
Lievense, J. ;
Covello, P. S. ;
Keasling, J. D. ;
Reiling, K. K. ;
Renninger, N. S. ;
Newman, J. D. .
NATURE, 2013, 496 (7446) :528-+
[9]   Synthetic malaria drug meets market resistance [J].
Peplow, Mark .
NATURE, 2016, 530 (7591) :389-390
[10]   The WRKY transcription factor AaGSW2 promotes glandular trichome initiation in Artemisia annua [J].
Xie, Lihui ;
Yan, Tingxiang ;
Li, Ling ;
Chen, Minghui ;
Ma, Yanan ;
Hao, Xiaolong ;
Fu, Xueqing ;
Shen, Qian ;
Huang, Yiwen ;
Qin, Wei ;
Liu, Hang ;
Chen, Tiantian ;
Hassani, Danial ;
Kayani, Sadaf-Llyas ;
Rose, Jocelyn K. C. ;
Tang, Kexuan .
JOURNAL OF EXPERIMENTAL BOTANY, 2021, 72 (05) :1691-1701