A Canadian case control study investigating demographic and environmental factors associated with MOGAD

被引:0
作者
Hosseini-Moghaddam, Sam [1 ]
Marrie, Ruth Ann [2 ,3 ]
Wolfson, Christina [4 ,5 ,6 ]
Carruthers, Robert [7 ]
Freedman, Mark S. [8 ,9 ]
Morrow, Sarah [10 ,11 ]
Lee, Liesly [12 ,13 ]
Nisenbaum, Rosane [13 ,14 ,15 ]
Konig, Andrea [1 ]
Magalhaes, Sandra [16 ]
Rotstein, Dalia L. [1 ,13 ,17 ]
机构
[1] St Michaels Hosp, 30 Bond St, Toronto, ON M5B 1W8, Canada
[2] Univ Manitoba, Max Rady Coll Med, Rady Fac Hlth Sci, Dept Med, Winnipeg, MB, Canada
[3] Univ Manitoba, Max Rady Coll Med, Rady Fac Hlth Sci, Dept Community Hlth Sci, Winnipeg, MB, Canada
[4] McGill Univ, Fac Med & Hlth Sci, Dept Epidemiol & Biostat, Montreal, PQ, Canada
[5] McGill Univ, Fac Med & Hlth Sci, Dept Occupat Hlth & Med, Montreal, PQ, Canada
[6] McGill Univ, Hlth Ctr, Res Inst, Montreal, PQ, Canada
[7] Univ British Columbia, Fac Med, Div Neurol, Vancouver, BC, Canada
[8] Univ Ottawa, Dept Med, Ottawa, ON, Canada
[9] Ottawa Hosp Res Inst, Ottawa, ON, Canada
[10] Western Univ, London, ON, Canada
[11] London Hlth Sci Ctr, London, ON, Canada
[12] Univ Toronto, Sunnybrook Hlth Sci Ctr, 2075 Bayview Ave, Toronto, ON, Canada
[13] Univ Toronto, Dept Med, 6 Queens Pk Crescent West,3rd floor, Toronto, ON M5S 3H2, Canada
[14] St Michaels Hosp, Li Ka Shing Knowledge Inst, Appl Hlth Res Ctr, MAP Ctr Urban Hlth Solut,Unity Hlth Toronto, Toronto, ON, Canada
[15] Univ Toronto, Dalla Lana Sch Publ Hlth, Div Biostat, Toronto, ON, Canada
[16] Univ New Brunswick, Dept Sociol, Fredericton, NB, Canada
[17] St Michaels Hosp, MS Clin, 30 Bond St, Toronto, ON M5B 1W8, Canada
关键词
MOGAD; Risk factors; Epidemiology; MULTIPLE-SCLEROSIS; RISK-FACTORS; OBESITY; AGE; DISEASE; PUBERTY; ENVIMS;
D O I
10.1016/j.msard.2023.105023
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Little is known about demographic and environmental factors associated with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD).Objective: To investigate factors associated with MOGAD using a case-control design and validated questionnaire from the Environmental Risk Factors in Multiple Sclerosis Study (EnvIMS).Methods: We enrolled patients with positive MOG antibody serology and diagnosis of MOGAD at six Canadian centres. MOGAD participants completed the EnvIMS questionnaire, and were compared to unaffected controls from the Canadian arm of EnvIMS. We calculated crude and adjusted odds ratios (OR) using logistic regression models and Firth's procedure for rare events.Results: We enrolled 39 MOGAD participants with mean (SD) age 45.0 (14.4) years, 28 (71.8 %) women, 25 (64.1 %) White, 26 (66.7 %) residents of Ontario, and mean BMI 28.6 (7.1). They were compared to 956 controls. Using multivariable logistic regression, larger body size at age 10 years (OR: 3.57, 95 % CI:1.23 - 10.33) and non-White ethnicity (OR:3.81, 95 % CI:1.93-7.54) were associated with higher odds of MOGAD. Among Ontario residents, current BMI >= 30 was associated with higher odds of MOGAD (OR:2.79, 95 % CI:1.03-7.53). Conclusion: Our findings are hypothesis-generating due to the sample size, but suggest that obesity and ethnicity should be explored as potential risk factors for MOGAD in other settings.
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页数:7
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