Changes in mucosal IgG4+- and IL-10+-cell frequencies in adults with eosinophilic esophagitis on a two-food elimination diet

被引：3

作者：

Appanna, Ramapraba ^{[1
]}

Gargano, Domenico ^{[2
]}

Caputo, Alessandro ^{[1
,3
]}

De Bartolomeis, Fabio ^{[2
]}

Ricciardi, Luca ^{[1
]}

Santonicola, Antonella ^{[1
,3
]}

Stefanelli, Berenice ^{[1
]}

Caiazza, Laura ^{[1
]}

Guarciariello, Marialuisa ^{[2
]}

D'Antonio, Antonio ^{[3
]}

D'Auria, Raffaella ^{[1
]}

Conti, Valeria ^{[1
,3
]}

Casolaro, Vincenzo ^{[1
,3
]}

Iovino, Paola ^{[1
,3
]}

机构：

[1] Univ Salerno, Dept Med Surg & Dent, Scuola Med Salernitana, Via S Allende, I-84081 Baronissi, Italy

[2] San Giuseppe Moscati Hosp, Avellino, Italy

[3] San Giovanni Dio & Ruggi Aragona Univ Hosp, Salerno, Italy

来源：

CLINICAL IMMUNOLOGY | 2023年 / 257卷

关键词：

Diet; Eosinophils; Esophagus; IgG4; IL-10; FOOD; MANAGEMENT; ASSOCIATION; GUIDELINES; DISEASE;

D O I：

10.1016/j.clim.2023.109853

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Eosinophilic esophagitis (EoE) is increasingly diagnosed in patients with dysphagia. Type-2 immunity can induce EoE histopathology via non-IgE-dependent mechanisms, possibly involving IgG4 and IL-10. To elucidate the contribution of this response to EoE pathogenesis, we examined its association with clinical and histologic endpoints in adult EoE patients given a two-food elimination diet. IgG4-and IL-10-expressing cells were counted in esophageal biopsies and serum food-specific IgG4 measured at baseline and follow-up. Variables were correlated with histologic measures of disease activity. Patients exhibited significant reduction in esophageal eosinophilia and overall histology. A significant decrease in IL-10+-cell frequencies correlated with histologic changes. In contrast, a decline in serum and esophageal IgG4, while substantial, did not correlate with IL-10+-cell frequencies or histologic parameters. These results suggest a critical role of IL-10 in EoE pathogenesis. Conversely, IgG4 expression, while reflecting exposure to food antigens, is not obviously related to EoE histo-pathology or IL-10 expression.

引用

页数：11