The proteinopenia hypothesis: Loss of Aβ42 and the onset of Alzheimer's Disease

被引：15

作者：

Espay, Alberto J. ^{[1
,6
]}

Herrup, Karl ^{[2
]}

Kepp, Kasper P. ^{[3
]}

Daly, Timothy ^{[4
,5
]}

机构：

[1] Univ Cincinnati, James J & Joan A Gardner Family Ctr Parkinsons Dis, Dept Neurol, Cincinnati, OH USA

[2] Univ Pittsburgh, Sch Med, Dept Neurobiol, Pittsburgh, PA USA

[3] Tech Univ Denmark, Dept Chem, Sect Biophys & Biomed Chem, DK-2800 Lyngby, Denmark

[4] Sorbonne Univ, Sci Norms Democracy, UMR 8011, Paris, France

[5] FLACSO Argentina, Bioeth Program, Tucuman 1966, Buenos Aires RA-C1050 AAN, Argentina

[6] Univ Cincinnati, Acad Hlth Ctr, 260 Stetson St,Suite 2300, Cincinnati, OH 45267 USA

来源：

AGEING RESEARCH REVIEWS | 2023年 / 92卷

关键词：

Loss of function; Alzheimer's disease; Soluble protein; A beta 42; Amyloid;

D O I：

10.1016/j.arr.2023.102112

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The dominant protein-lowering strategy in Alzheimer's Disease (AD) has failed to provide a clinically-meaningful treatment for patients. We hypothesize that the loss of functional, soluble A beta 42 during the process of aggregation into amyloid is more detrimental to the brain than the corresponding accrual of insoluble amyloid.

引用

页数：5

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