Identification of circulating proteins associated with general cognitive function among middle-aged and older adults

被引：8

作者：

Tin, Adrienne ^{[1
,2
,14
]}

Fohner, Alison E. ^{[3
,4
,5
]}

Yang, Qiong ^{[6
]}

Brody, Jennifer A. ^{[5
]}

Davies, Gail ^{[7
]}

Yao, Jie ^{[8
]}

Liu, Dan ^{[9
]}

Caro, Ilana ^{[10
]}

Lindbohm, Joni V. ^{[11
,12
,13
,14
]}

Duggan, Michael R. ^{[15
]}

Meirelles, Osorio ^{[16
]}

Harris, Sarah E. ^{[7
]}

Gudmundsdottir, Valborg ^{[17
,18
]}

Taylor, Adele M. ^{[7
]}

Henry, Albert ^{[19
]}

Beiser, Alexa S. ^{[6
,20
]}

Shojaie, Ali ^{[21
]}

Coors, Annabell ^{[9
]}

Fitzpatrick, Annette L. ^{[3
,22
]}

Langenberg, Claudia ^{[23
,24
,25
]}

Satizabal, Claudia L. ^{[20
,26
,27
,28
]}

Sitlani, Colleen M. ^{[5
]}

Wheeler, Eleanor ^{[24
]}

Tucker-Drob, Elliot M. ^{[29
]}

Bressler, Jan ^{[30
]}

Coresh, Josef ^{[31
]}

Bis, Joshua C. ^{[5
]}

Candia, Julian ^{[32
]}

Jennings, Lori L. ^{[33
]}

Pietzner, Maik ^{[23
,24
,25
]}

Lathrop, Mark ^{[34
]}

Lopez, Oscar L. ^{[35
,36
]}

Redmond, Paul ^{[7
]}

Gerszten, Robert E. ^{[37
]}

Rich, Stephen S. ^{[38
]}

Heckbert, Susan R. ^{[3
]}

Austin, Thomas R. ^{[3
,5
]}

Hughes, Timothy M. ^{[39
,40
]}

Tanaka, Toshiko ^{[32
]}

Emilsson, Valur ^{[17
,18
]}

Vasan, Ramachandran S. ^{[20
,41
,42
]}

Guo, Xiuqing ^{[8
]}

Zhu, Yineng ^{[6
]}

Tzourio, Christophe ^{[10
]}

Rotter, Jerome I. ^{[8
]}

Walker, Keenan A. ^{[15
]}

Ferrucci, Luigi ^{[32
]}

Kivimaki, Mika ^{[43
,44
]}

Breteler, Monique M. B. ^{[9
,45
]}

Cox, Simon R. ^{[7
]}

机构：

[1] Univ Mississippi, Med Ctr, MIND Ctr, Jackson, MS 39216 USA

[2] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA

[3] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA

[4] Univ Washington, Inst Publ Hlth Genet, Seattle, WA 98195 USA

[5] Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA

[6] Boston Univ, Dept Biostat, Boston, MA USA

[7] Univ Edinburgh, Dept Psychol, Lothian Birth Cohorts, 7 George Sq, Edinburgh EH8 9JZ, Midlothian, Scotland

[8] Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Lundquist Inst Biomed Innovat, Dept Pediat, Torrance, CA USA

[9] German Ctr Neurodegenerat Dis DZNE, Populat Hlth Sci, Bonn, Germany

[10] Univ Bordeaux, INSERM, Bordeaux Populat Hlth Res Ctr, CHU Bordeaux,UMR 1219, Bordeaux, France

[11] MIT, Klarman Cell Observ, Broad Inst, Cambridge, MA USA

[12] Harvard Univ, Klarman Cell Observ, Broad Inst, Cambridge, MA USA

[13] Univ Helsinki, Dept Publ Hlth, Clinicum, Helsinki, Finland

[14] UCL, Dept Epidemiol & Publ Hlth, London, England

[15] NIA, Lab Behav Neurosci, Baltimore, MD USA

[16] NIA, NIH, Lab Epidemiol & Populat Sci, Bethesda, MD USA

[17] Univ Iceland, Fac Med, Reykjavik, Iceland

[18] Iceland Heart Assoc, Kopavogur, Iceland

[19] Univ London, Inst Cardiovasc Sci, London, England

[20] Framingham Heart Dis Epidemiol Study, Framingham, MA USA

[21] Univ Washington, Dept Biostat, Seattle, WA USA

[22] Univ Washington, Dept Family Med, Seattle, WA USA

[23] Queen Mary Univ London, Precis Healthcare Inst, London, England

[24] Univ Cambridge, MRC Epidemiol Unit, Cambridge, England

[25] Charite Univ Med Berlin, Berlin Inst Hlth, Computat Med, Berlin, Germany

[26] UT Hlth San Antonio, Dept Populat Hlth Sci, San Antonio, TX USA

[27] UT Hlth San Antonio, Glenn Biggs Inst Alzheimers & Neurodegenerat Dis, San Antonio, TX USA

[28] Boston Univ, Dept Neurol, Sch Med, Boston, MA USA

[29] Univ Texas Austin, Dept Psychol, Austin, TX USA

[30] Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Ctr Human Genet, Houston, TX USA

[31] Johns Hopkins Univ, Baltimore, MD USA

[32] NIA, Translat Gerontol Branch, Baltimore, MD USA

[33] Novartis Inst Biomed Res, 22 Windsor St, Cambridge, MA USA

[34] McGill Genome Ctr, Montreal, PQ, Canada

[35] Univ Pittsburgh, Dept Neurol, Pittsburgh, PA USA

[36] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA

[37] Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA USA

[38] Univ Virginia, Ctr Publ Hlth Genom, Dept Publ Hlth Sci, Charlottesville, VA USA

[39] Wake Forest Sch Med, Dept Internal Med, Sect Gerontol & Geriatr Med, Winston Salem, NC USA

[40] Wake Forest Univ, Dept Epidemiol & Prevent, Sch Med, Winston Salem, NC USA

[41] Univ Texas Sch Publ Hlth San Antonio, San Antonio, TX USA

[42] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX USA

[43] UCL, UCL Brain Sci, London, England

[44] Univ Helsinki, Clinicum, Fac Med, Helsinki, Finland

[45] Univ Bonn, Fac Med, IMBIE, Bonn, Germany

[46] CHU Bordeaux, Dept Neurol, Inst Neurodegenerat Dis, Bordeaux, France

[47] NIA, Lab Epidemiol & Populat Sci, NIH, Baltimore, MD USA

[48] Univ Washington, Dept Hlth Syst & Populat Hlth, Seattle, WA USA

[49] Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Inst Mol Med, Houston, TX USA

来源：

COMMUNICATIONS BIOLOGY | 2023年 / 6卷 / 01期

基金：

美国国家卫生研究院; 英国生物技术与生命科学研究理事会;

关键词：

C-REACTIVE PROTEIN; GENOME-WIDE ASSOCIATION; MENDELIAN RANDOMIZATION; ALZHEIMERS-DISEASE; KIDNEY-FUNCTION; DEMENTIA; PLASMA; RISK; INSTRUMENTS; EXPRESSION;

D O I：

10.1038/s42003-023-05454-1

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Identifying circulating proteins associated with cognitive function may point to biomarkers and molecular process of cognitive impairment. Few studies have investigated the association between circulating proteins and cognitive function. We identify 246 protein measures quantified by the SomaScan assay as associated with cognitive function (p<4.9E-5, n up to 7289). Of these, 45 were replicated using SomaScan data, and three were replicated using Olink data at Bonferroni-corrected significance. Enrichment analysis linked the proteins associated with general cognitive function to cell signaling pathways and synapse architecture. Mendelian randomization analysis implicated higher levels of NECTIN2, a protein mediating viral entry into neuronal cells, with higher Alzheimer's disease (AD) risk (p=2.5E-26). Levels of 14 other protein measures were implicated as consequences of AD susceptibility (p<2.0E-4). Proteins implicated as causes or consequences of AD susceptibility may provide new insight into the potential relationship between immunity and AD susceptibility as well as potential therapeutic targets. Analysis of circulating proteins across multiple cohorts identifies proteins that are associated with cognitive function and may serve as targets to understand the relationship between immunity and Alzheimer's disease risk.

引用

页数：14

共 50 条

[1] Residential Mobility and Cognitive Function Among Middle-Aged and Older Adults in China
Xu, Hanzhang
Dupre, Matthew E.
Ostbye, Truls
Vorderstrasse, Allison A.
Wu, Bei
RESEARCH ON AGING, 2019, 41 (01) : 3 - 30
[2] Effects of Participation in Social Activities on Cognitive Function Among Middle-Aged and Older Adults in Korea
Hwang, Jongnam
Park, Sangmin
Kim, Sujin
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2018, 15 (10)
[3] Exploring the reciprocal relationship between cognitive function and edentulism among middle-aged and older adults in China
Lu, Nan
Wu, Bei
Pei, Yaolin
AGE AND AGEING, 2021, 50 (03) : 809 - 814
[4] Incidence and risk factors associated with progression to mild cognitive impairment among middle-aged and older adults
Zhang, N. -J
Qian, Z. -D
Zeng, Y. -B
Gu, J. -N
Jin, Y.
Li, W.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2022, 26 (23) : 8852 - 8859
[5] Psychological profiles associated with mental, cognitive and brain health in middle-aged and older adults
Bartres-Faz, David
Demnitz-King, Harriet
Cabello-Toscano, Maria
Vaque-Alcazar, Lidia
Saunders, Rob
Touron, Edelweiss
Cattaneo, Gabriele
Gonneaud, Julie
Klimecki, Olga
Bargallo, Nuria
Sanchez-Solana, Javier
Tormos, Jose M.
Chetelat, Gael
Pascual-Leone, Alvaro
Marchant, Natalie L.
Andre, Claire
Bachelet, Romain
Baez Lugo, Sebastian
Chocat, Anne
Collette, Fabienne
Coll-Padros, Nina
Dautricourt, Sophie
de la Sayette, Vincent
Delarue, Marion
Ferrand Devouge, Eglantine
Frison, Eric
Goldet, Karine
Jessen, Frank
Krolak-Salmon, Pierre
Kuhn, Elizabeth
Landeau, Brigitte
Lefranc, Valerie
Lutz, Antoine
Mezenge, Florence
Meiberth, Dix
Michel, Laurence
Molinuevo, Jose Luis
Ourry, Valentin
Poisnel, Geraldine
Quillard, Anne
Rauchs, Geraldine
Salmon, Eric
Schild, Ann-Katrin
Schimmer, Corinne
Smagghe, Delphine
Smith, Rhonda
Schlosser, Marco
Vuilleumier, Patrik
Wallet, Cedrick
Walker, Zuzana
NATURE MENTAL HEALTH, 2025, 3 (01): : 92 - 103
[6] Correlates of cognitive function in middle-aged adults
Cerhan, JR
Folsom, AR
Mortimer, JA
Shahar, E
Knopman, DS
McGovern, PG
Hays, MA
Crum, LD
Heiss, G
GERONTOLOGY, 1998, 44 (02) : 95 - 105
[7] Relationship of smoking cessation duration and cognitive function among middle-aged and older adults in China: a national cross-sectional study
Zuo, Wenhang
Peng, Jin
Wu, Jinhui
FRONTIERS IN PUBLIC HEALTH, 2025, 12
[8] The interrelationships of hearing function, allostatic load, and cognitive function: Evidence among middle-aged and older Chinese adults
Yang, Lei
Luo, Yanan
ARCHIVES OF GERONTOLOGY AND GERIATRICS, 2024, 117
[9] The Long Arm of Childhood in China: Early-Life Conditions and Cognitive Function Among Middle-Aged and Older Adults
Zhang, Zhenmei
Liu, Jinyu
Li, Lydia
Xu, Hongwei
JOURNAL OF AGING AND HEALTH, 2018, 30 (08) : 1319 - 1344
[10] Longitudinal association between visual disability and cognitive function among middle-aged and older adults in China
He, Ye
Song, Weitao
Jiang, Xin
Wang, Chao
Zhou, Yi
Lu, Bing
Zhou, Minwen
BRITISH JOURNAL OF OPHTHALMOLOGY, 2023, 107 (07) : 1025 - 1030

← 1 2 3 4 5 →