Effect of OPRM1/COMT gene polymorphisms on sufentanil labor analgesia: a cohort study based on propensity score matching

被引：4

作者：

Chen, Yao ^{[1
]}

Chen, Quanyao ^{[1
]}

Cai, Can ^{[1
]}

Lin, Xiuxian ^{[1
]}

Yu, Weiwei ^{[1
]}

Huang, Huiqiong ^{[1
]}

Xie, Wenmin ^{[1
]}

Lin, Min ^{[1
]}

Chen, Weida ^{[1
]}

Wu, Hui ^{[2
]}

Su, Tingting ^{[3
]}

Wang, Lingsong ^{[1
]}

机构：

[1] Xiamen Univ, Women & Childrens Hosp, Sch Med, Xiamen 361003, Fujian, Peoples R China

[2] Xiamen Univ, Sch Pharmaceut Sci, Xiamen 361003, Fujian, Peoples R China

[3] Fujian Med Univ, Fuzhou 350000, Fujian, Peoples R China

来源：

PHARMACOGENOMICS | 2023年 / 24卷 / 12期

关键词：

analgesia; COMT; labor; OPRM1; sufentanil; OPIOID RECEPTOR GENE; CONTROLLED EPIDURAL ANALGESIA; A118G POLYMORPHISM; ROPIVACAINE; ASSOCIATION; PAIN; LEVOBUPIVACAINE;

D O I：

10.2217/pgs-2023-0103

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Background: This study investigated the use of COMT G1947A and OPRM1 A118G polymorphisms as predictive markers for sufentanil epidural analgesia. Methods: The visual analogue scale (VAS) score, and sufentanil consumption of 136 pairs of parturients using sufentanil with lidocaine and ropivacaine for epidural analgesia were used for analysis. Results: OPRM1 AG/GG had lower VAS score difference between fifth and 0 min (1.55 vs 1.87; p = 0.012) and higher consumption (19.65 mu g vs 17.11 mu g; p = 0.049) than AA carriers. COMT GA/AA had higher VAS score difference than GG carriers (1.86 vs 1.55; p = 0.021). Conclusion: Sufentanil may provide better epidural labor analgesia in OPRM1 AA and COMT GA/AA carriers compared with OPRM1 AG/GG and COMT GG carriers.

引用

页码：675 / 684

页数：10

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