Undescribed sesquiterpene-diterpene heterodimers from the fruits of Aphanamixis polystachya selectively modulate inflammatory markers in RAW 264.7 cells

被引：6

作者：

Tai, Bui Huu ^{[1
]}

Bang, Ngo Anh ^{[1
,2
]}

Yen, Pham Hai ^{[1
]}

Yen, Duong Thi Hai ^{[1
]}

Cuc, Nguyen Thi ^{[1
]}

Dung, Duong Thi ^{[1
]}

Huong, Phan Thi Thanh ^{[1
]}

Trang, Do Thi ^{[1
]}

Nhiem, Nguyen Xuan ^{[1
]}

Cuong, Nguyen The ^{[3
]}

Van Kiem, Phan ^{[1
,4
]}

机构：

[1] Vietnam Acad Sci & Technol VAST, Inst Marine Biochem, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam

[2] Grad Univ Sci & Technol, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam

[3] Vietnam Acad Sci & Technol VAST, Inst Ecol & Biol Resources, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam

[4] Vietnam Acad Sci & Technol, Inst Marine Biochem, Dept Struct Res, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam

来源：

PHYTOCHEMISTRY | 2024年 / 220卷

关键词：

Aphanamixis polystachya; Meliaceae; Aphanapolystachone; Sesquiterpene-diterpene heterodimer; Anti-inflammatory activity; A-D; DIMERS; CONSTITUENTS;

D O I：

10.1016/j.phytochem.2024.113997

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aphanapolystachones A-C (1-3), three undescribed sesquiterpene-diterpene heterodimers, were obtained from the fruits of Aphanamixis polystachya. Their structures and absolute configurations were identified by extensive analysis of HR-ESI-MS, NMR, experimental and TD-DFT calculated ECD spectra. The biosynthetic pathway of them was also proposed, which is produced by key intermolecular Diels-Alder [4 + 2]-cycloaddition reaction between a guaiane sesquiterpene and an acyclic diterpene. Compounds 1-3 inhibited NO production in LPS activated RAW 264.7 cells with the IC50 values of 1.7 +/- 0.2, 3.0 +/- 0.3, 5.3 +/- 0.3 mu M, respectively, lower than that of the positive control L-NMMA (31.5 +/- 2.6 mu M). In addition, compounds 1-3 significantly reduced IL -6 secretion at diluted concentration of 0.4 mu M.

引用

页数：7

共 20 条

[1] Oxygenated terpenoids from a Formosan soft coral Sinularia gibberosa [J].