New protein-protein interactions designed by a computer

被引：2

作者：

Marchand, Anthony ^{[1
]}

Gainza, Pablo ^{[2
]}

机构：

[1] Swiss Fed Inst Technol Lausanne, Lausanne, Switzerland

[2] Monte Rosa Therapeut, Basel, Switzerland

来源：

NATURE | 2023年

关键词：

Computational biology and bioinformatics; Synthetic biology;

D O I：

10.1038/d41586-023-01324-2

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Creating protein interactions through computational design is a key challenge in the fields of both basic and translational biology. An approach that uses the machine-learned fingerprints of protein-surface features was used to produce synthetic proteins that engage immunotherapeutic or viral targets with binding affinities comparable to those of naturally occurring proteins.

引用

页数：2

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