Efficacy and safety of bivalirudin bridging enoxaparin versus fondaparinux in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention: evidence from a single-center study

被引：1
作者：
Guo, Yanqing [1 ]
Wang, Jingping [1 ]
Wang, Zhixin [1 ]
Li, Li [1 ]
An, Jian [1 ]
机构：
[1] Shanxi Cardiovasc Hosp, Dept Cardiol, Taiyuan, Shanxi, Peoples R China
来源：
ARCHIVES OF MEDICAL SCIENCE | 2023年 / 19卷 / 01期
关键词：
fondaparinux; bivalirudin; enoxaparin; acute myocardial infarction; primary percutaneous coronary intervention; UNFRACTIONATED HEPARIN; METAANALYSIS; MONOTHERAPY;
D O I：
10.5114/aoms/157287
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Introduction: This study aims to compare the safety and efficacy of bivalirudin bridging enoxaparin versus fondaparinux in patients with acute myocardial infarction (AMI) who were undergoing primary percutaneous coronary intervention (PPCI). Methods: The study is a prospective, natural, and selective interventional trial based on real- world data for 482 AMI patients. Results: At the end of the follow-up, the two groups demonstrated similar major adverse cardiovascular and cerebrovascular events (MACCE) and bleeding rates. After propensity score matching (PSM), the fondaparinux group showed greater advantages in reducing MACCE and bleeding events. Conclusions: The anticoagulation strategy of bivalirudin bridging fondaparinux seems to be superior to that of bivalirudin bridging enoxaparin in patients with AMI undergoing PPCI.
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收藏
页码：242 / 249
页数：8
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