Transcriptional and epigenetic regulation of microglia in maintenance of brain homeostasis and neurodegeneration

被引：7
作者：
Maurya, Shashank Kumar [1 ]
Gupta, Suchi [2 ]
Mishra, Rajnikant [3 ]
机构：
[1] Univ Delhi, Dept Zool, Biochem & Mol Biol Lab, New Delhi, India
[2] All India Inst Med Sci, Tech Cell Innovat Pvt Ltd, Ctr Med Innovat & Entrepreneurship CMIE, New Delhi, India
[3] Banaras Hindu Univ, Dept Zool, Biochem & Mol Biol Lab, Varanasi, India
来源：
FRONTIERS IN MOLECULAR NEUROSCIENCE | 2023年 / 15卷
关键词：
microglia; brain homeostasis; transcription factors; epigenetic changes; brain immunity; neurological diseases; NF-KAPPA-B; MITOCHONDRIAL DYSFUNCTION; PARKINSONS-DISEASE; GENE-EXPRESSION; SPINAL-CORD; ACTIVATION; PU.1; INFLAMMATION; CELLS; RECEPTOR;
D O I：
10.3389/fnmol.2022.1072046
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The emerging role of microglia in brain homeostasis, neurodegeneration, and neurodevelopmental disorders has attracted considerable interest. In addition, recent developments in microglial functions and associated pathways have shed new light on their fundamental role in the immunological surveillance of the brain. Understanding the interconnections between microglia, neurons, and non-neuronal cells have opened up additional avenues for research in this evolving field. Furthermore, the study of microglia at the transcriptional and epigenetic levels has enhanced our knowledge of these native brain immune cells. Moreover, exploring various facets of microglia biology will facilitate the early detection, treatment, and management of neurological disorders. Consequently, the present review aimed to provide comprehensive insight on microglia biology and its influence on brain development, homeostasis, management of disease, and highlights microglia as potential therapeutic targets in neurodegenerative and neurodevelopmental diseases.
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页数：21
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