Recent Literature on the Synthesis of Thiazole Derivatives and their Biological Activities

被引：12

作者：

Farghaly, Thoraya A. ^{[1
]}

Alfaifi, Ghaidaa H. ^{[1
]}

Gomha, Sobhi M. ^{[2
,3
]}

机构：

[1] Umm Al Qura Univ, Fac Appl Sci, Dept Chem, Makkah Almukaramah 21514, Saudi Arabia

[2] Islamic Univ Madinah, Fac Sci, Dept Chem, Madinah 42351, Saudi Arabia

[3] Cairo Univ, Fac Sci, Dept Chem, Giza, Egypt

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2024年 / 24卷 / 02期

关键词：

Thiazoles; synthesis; biological activity; anticancer; antimicrobial; disease; MOLECULAR DOCKING; DESIGN; SERIES; INHIBITORS; CANCER;

D O I：

10.2174/1389557523666230726142459

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The thiazole ring is naturally occurring and is primarily found in marine and microbial sources. It has been identified in various compounds such as peptides, vitamins (thiamine), alkaloids, epothilone, and chlorophyll. Thiazole-containing compounds are widely recognized for their antibacterial, antifungal, anti-inflammatory, antimalarial, antitubercular, antidiabetic, antioxidant, anticonvulsant, anticancer, and cardiovascular activities. The objective of this review is to present recent advancements in the discovery of biologically active thiazole derivatives, including their synthetic methods and biological effects. This review comprehensively discusses the synthesis methods of thiazole and its corresponding biological activities within a specific timeframe, from 2017 until the conclusion of 2022.

引用

页码：196 / 251

页数：56

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