Three-Dimensional Cell Culture System for Tendon Tissue Engineering

被引：8
作者：
Son, Young Hoon [1 ]
Yang, Dae Hyeok [2 ]
Uricoli, Biaggio [3 ]
Park, Sung-Jin [1 ]
Jeong, Gun-Jae [2 ]
Chun, Heung Jae [2 ]
机构：
[1] Emory Univ, Georgia Inst Technol, Sch Med, Coulter Dept Biomed Engn,Biohybrid Syst Grp, Atlanta, GA 30322 USA
[2] Catholic Univ Korea, Inst Cell & Tissue Engn, Coll Med, Seoul 06591, South Korea
[3] Emory Univ, Georgia Inst Technol, Coulter Dept Biomed Engn, Atlanta, GA 30322 USA
来源：
TISSUE ENGINEERING AND REGENERATIVE MEDICINE | 2023年 / 20卷 / 04期
关键词：
3D cell culture; Tendon; Tissue engineering; Tenocyte; ACHILLES-TENDON; EXTRACELLULAR-MATRIX; BASIC SCIENCE; REPAIR; SCAFFOLD; EFFICACY; LIGAMENT; DIFFERENTIATION; IDENTIFICATION; TENDINOPATHY;
D O I：
10.1007/s13770-023-00550-z
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Tendon, connective tissue between bone and muscle has unique component of the musculoskeletal system. It plays important role for transporting mechanical stress from muscle to bone and enabling locomotive motion of the body. There are some restoration capacities in the tendon tissue, but the injured tendons are not completely regenerated after acute and chronic tendon injury. At this point, the treatment options for tendon injuries are limited and not that successful. Therefore, biomedical engineering approaches are emerged to cope with this issue. Among them, three-dimensional cell culture platforms provided similarity to in vivo conditions and suggested opportunities for new therapeutic approaches for treatment of tendon injuries. In this review, we focus on the characteristics of tendon tissue and tendon pathologies which can be targets for tendon tissue engineering strategies. Then proof-of-concept and pre-clinical studies leveraging advanced 3-dimensional cell culture platforms for tendon tissue regeneration have been discussed.
引用
收藏
页码：553 / 562
页数：10
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