Homalolides C-D, two new sesquiterpenoids from the rhizomes of Homalomena pendula

被引：5

作者：

Linh Thuy Khanh Nguyen ^{[1
,3
]}

Hanh Nhu Thi Hoang ^{[2
]}

Thi Van Anh Tran ^{[3
]}

Hoai Thi Nguyen ^{[1
]}

Duc Viet Ho ^{[1
]}

机构：

[1] Hue Univ, Hue Univ Med & Pharm, Fac Pharm, Hue City, Vietnam

[2] Hue Univ, Hue Univ Agr & Forestry, Fac Engn & Food Technol, Hue City, Vietnam

[3] Univ Med & Pharm Ho Chi Minh City, Fac Pharm, Ho Chi Minh City, Vietnam

来源：

NATURAL PRODUCT RESEARCH | 2024年 / 38卷 / 01期

关键词：

Araceae; homalolides C-D; Homalomena pendula; sesquiterpenoid; ROOTS;

D O I：

10.1080/14786419.2022.2103557

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two new sesquiterpenoids, homalolides C - D (1-2), were co-isolated from the rhizomes of Homalomena pendula (Blume) Bakh.f collected in Vietnam with five known ones, aromadendrane-4 alpha,10 alpha-diol (3), bullatantriol (4), 1 beta,4 beta,6 alpha-trihydroxy-eudesmane (5), 1 beta,4 beta,6 beta-trihydroxyeudesmane (6), and 1 beta,4 beta,7 alpha-trihydroxy-eudesmane (7). The structures and relative configuration of new compounds were elucidated by 1 D-/2D-NMR, IR, UV and HRESIMS analyses, and by comparisons to the reported data in the literature. Homalolide C presented an unprecedented skeleton with the 4/8 bicyclic system. All isolates did not exhibit appreciable inhibitory effects on LPS-induced NO production in the RAW 264.7 macrophage cell line and on the growth of human lung cancer cell line (SK-LU-1).

引用

页码：60 / 67

页数：8

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