Carbon dots/platinum nanoparticles-loaded mesoporous silica for synergistic photodynamic/catalytic therapy of hypoxic tumors

被引：8

作者：

Liang, Ke ^{[1
,2
,4
]}

Zhao, Fanghao ^{[3
]}

Nan, Fuchun ^{[1
,2
,4
]}

Wang, Jian ^{[1
,2
,4
]}

Zhang, Yunxiu ^{[1
,2
,4
]}

Li, Jian ^{[1
,2
,4
]}

Xue, Xiaokuang ^{[1
,2
,4
]}

Chen, Tiejin ^{[1
,2
,4
]}

Kong, Lin ^{[1
,2
,4
]}

Ge, Jiechao ^{[1
,2
,4
]}

Wang, Pengfei ^{[1
,2
,4
]}

机构：

[1] Chinese Acad Sci, Tech Inst Phys & Chem, Key Lab Photochem Convers & Optoelect Mat, Beijing 100049, Peoples R China

[2] Chinese Acad Sci, Tech Inst Phys & Chem, CityU CAS Joint Lab Funct Mat & Devices, Beijing 100049, Peoples R China

[3] Univ Manchester, G020 Chem Bldg, Manchester M13 9PL, England

[4] Univ Chinese Acad Sci, Sch Future Technol, Beijing 100049, Peoples R China

来源：

MATERIALS CHEMISTRY FRONTIERS | 2023年 / 7卷 / 13期

基金：

中国国家自然科学基金;

关键词：

CANCER; DOTS; NANOZYME; THERANOSTICS; AGENT;

D O I：

10.1039/d3qm00008g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The therapeutic efficacy of reactive oxygen species (ROS)-mediated cancer treatments is significantly limited by a shortage of substrates, such as hypoxia in photodynamic therapy (PDT). The development of an effective nanoplatform based on PDT toward hypoxic tumors remains a research imperative. Here, we report a triple ROS-generator, hyaluronic acid-modified Pt nanoparticles/carbon dots-loaded mesoporous silica (HA-PCD), which consists of Pt nanoparticles (NPs) and carbon dots (CDs)-loaded dendritic mesoporous silica nanoparticles (DMSNs) with further surface modifying hyaluronic acid (HA) for photodynamic/catalytic combination therapy of hypoxic tumors. Under 635 nm laser irradiation, HA-PCD generates singlet oxygen (O-1(2)) due to the involvement of CDs photosensitizers. The loaded Pt NPs can not only enhance photodynamic therapy under hypoxic conditions by producing oxygen via catalase-mimicking activity, but also generate hydroxyl radicals (OH) and superoxide anions (O-2(-)) for catalytic therapy because of its peroxidase- and oxidase-mimicking activities. Additionally, due to the interaction between HA and overexpressed receptors (cluster determinant 44) in cancer cells, HA-PCD exhibits tumor cell targetability. In this work, a novel nanoplatform for multiple ROS-mediated synergistic photodynamic/catalytic therapy of hypoxic tumors has been fabricated.

引用

页码：2706 / 2720

页数：15

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