PET Imaging of Self-Assembled 18F-Labelled Pd2L4 Metallacages for Anticancer Drug Delivery

被引：18

作者：

Cosialls, Raul ^{[1
,3
]}

Simo, Cristina ^{[2
,3
]}

Borros, Salvador ^{[4
]}

Gomez-Vallejo, Vanessa ^{[2
]}

Schmidt, Claudia ^{[5
]}

Llop, Jordi ^{[2
]}

Cuenca, Ana B. ^{[1
,6
]}

Casini, Angela ^{[5
,7
]}

机构：

[1] URL, Dept Organ & Pharmaceut Chem, Inst Quim Sarria, BISi Bonds Grp, Via Augusta 390, Barcelona 08017, Spain

[2] Basque Res & Technol Alliance BRTA, CIC biomaGUNE, Paseo Miramon 182, San Sebastian 20014, Gipuzkoa, Spain

[3] Univ Pais Vasco UPV EHU, Dept Organ & Inorgan Chem, Barrio Sarriena S-N, Leioa 48940, Bizkaia, Spain

[4] URL, Inst Quim Sarria, Grp Engn Mat GEMAT, Via Augusta 390, Barcelona 08017, Spain

[5] Tech Univ Munich, Dept Chem, Chair Med & Bioinorgan Chem, Lichtenbergstr 4, D-85748 Garching, Germany

[6] Ctr Innovac Quim Avanzada ORFEO CINQA, Madrid, Spain

[7] Tech Univ Munich, Munich Data Sci Inst, D-85748 Garching, Germany

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2023年 / 29卷 / 03期

关键词：

ammonium trifluoroborates; cisplatin; drug delivery; metallacages; PET imaging; self-assembly; SUPRAMOLECULAR COORDINATION-COMPLEXES; PALLADIUM CAGES; ENCAPSULATION; STRATEGIES; SYSTEMS;

D O I：

10.1002/chem.202202604

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

To advance the design of self-assembled metallosupramolecular architectures as new generation theranostic agents, the synthesis of F-18-labelled [Pd2L4](4+) metallacages is reported. Different spectroscopic and bio-analytical methods support the formation of the host-guest cage-cisplatin complex. The biodistribution profiles of one of the cages, alone or encapsulating cisplatin have been studied by PET/CT imaging in healthy mice in vivo, in combination to ICP-MS ex vivo.

引用

页数：7

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