Some Aspects of α-(Acyloxy)alkyl Radicals in Organic Synthesis

被引：1

作者：

Quiclet-Sire, Beatrice ^{[1
]}

Zard, Samir Z. ^{[1
]}

机构：

[1] Ecole Polytech, Lab Synth Organ Associe, CNRS, UMR 7652, F-91128 Palaiseau, France

来源：

MOLECULES | 2023年 / 28卷 / 22期

关键词：

radical additions; xanthates; alpha-(acyloxy)alkyl radicals; enones; ALLYLIC ALCOHOLS; MODULAR APPROACH; CONVERGENT; ROUTE; XANTHATE; ACCESS; DERIVATIVES; ALKYLATION; ALLYLATION; CHEMISTRY;

D O I：

10.3390/molecules28227561

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The preparation and use of alpha-(acyloxy)alkyl xanthates to generate and capture alpha-(acyloxy)alkyl radicals is briefly reviewed. Their inter- and intramolecular additions to both activated and unactivated, electronically unbiased, alkenes, and to (hetero)aromatic rings, as well as their radical allylation and vinylation reactions are described. Application to the total synthesis of two 4-hydroxytetralone natural products is also presented.

引用

页数：22

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