Alcohol-Associated Liver Disease: Integrated Management With Alcohol Use Disorder

被引:26
作者
Arab, Juan P. [1 ,2 ,3 ,7 ,8 ]
Addolorato, Giovanni [4 ]
Mathurin, Philippe [5 ]
Thursz, Mark R. [6 ]
机构
[1] Western Univ, Schulich Sch Med, Dept Med, Div Gastroenterol, London, ON, Canada
[2] London Hlth Sci Ctr, London, ON, Canada
[3] Pontificia Univ Catolica Chile, Escuela Med, Dept Gastroenterol, Santiago, Chile
[4] Univ Cattolica Sacro Cuore, Dept Med & Surg Sci, Internal Med & Hepatol Unit, Rome, Italy
[5] Ctr Hosp Univ Lille, Hop Huriez, Serv Malad Appareil Digest, Lille, France
[6] Imperial Coll, Div Digest Dis, London, England
[7] Western Univ, Univ Hosp, Div Gastroenterol & Hepatol, 339 Windermere Rd,Room A10-224, London, ON N6A 5A5, Canada
[8] Univ Hosp, London Hlth Sci Ctr, 339 Windermere Rd,Room A10-224, London, ON N6A 5A5, Canada
基金
英国医学研究理事会;
关键词
Alcohol; Cirrhosis; Alcohol-Associated Hepatitis; Alcohol Use Disorder; Fatty Liver Disease; PRACTICE GUIDELINE; N-ACETYLCYSTEINE; CLINICAL-TRIALS; LILLE MODEL; HEPATITIS; TRANSPLANTATION; MORTALITY; PREDICTS; AUDIT; CORTICOSTEROIDS;
D O I
10.1016/j.cgh.2023.02.017
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Alcohol-associated liver disease (ALD) is the most common cause of cirrhosis and liver-related mortality in many re-gions worldwide. Around 75% of patients with cirrhosis are unaware of their disease until they are referred to the emergency department. An innovative, noninvasive screening approach is required for an earlier diagnosis of liver fibrosis. In patients with ALD the physician is inevi-tably dealing with 2 major disorders: the liver disease it-self and the alcohol use disorder (AUD). Focus only on the liver disease will inevitably lead to failure because tran-sient improvements in liver function are rapidly over-turned if the patient returns to alcohol consumption. For this reason, integrated models of care provided by hep-atologists and addiction specialists are an effective approach, which are, however, not widely available. There are multiple pharmacologic and non-pharmacologic ther-apies for AUD. Progress has recently been made in the management of patients with severe AH who have improved survival through better understanding of the concept of response to medical treatment, improved sur-vival prediction, and the advent of early liver trans-plantation. The emerging concept is that listing for transplantation a patient with severe ALD could lead to adjusting the duration of abstinence according to the severity and evolution of liver dysfunction and the pa-tient's addictive profile.
引用
收藏
页码:2124 / 2134
页数:11
相关论文
共 50 条
[21]   Therapeutic Pipeline in Alcohol-Associated Liver Disease [J].
Thakral, Nimish ;
Deutsch-Link, Sasha ;
Singal, Ashwani K. .
SEMINARS IN LIVER DISEASE, 2023, 43 (01) :60-76
[22]   Role of the ghrelin system in alcohol use disorder and alcohol-associated liver disease: A narrative review [J].
Kharbanda, Kusum K. ;
Farokhnia, Mehdi ;
Deschaine, Sara L. ;
Bhargava, Raghav ;
Rodriguez-Flores, Marcela ;
Casey, Carol A. ;
Goldstone, Anthony P. ;
Jerlhag, Elisabet ;
Leggio, Lorenzo ;
Rasineni, Karuna .
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH, 2022, 46 (12) :2149-2159
[23]   Treating Alcohol Use Disorder in Patients with Alcohol-Associated Liver Disease: Controversies in Pharmacological Therapy [J].
Tarli, Claudia ;
Mirijello, Antonio ;
Addolorato, Giovanni .
SEMINARS IN LIVER DISEASE, 2022, 42 (02) :138-150
[24]   Liver transplantation for alcohol-associated hepatitis [J].
Durkin, Claire ;
Bittermann, Therese .
CURRENT OPINION IN ORGAN TRANSPLANTATION, 2023, 28 (02) :85-94
[25]   Psychotherapy for Alcohol Use Disorder Is Associated With Reduced Risk of Incident Alcohol-Associated Liver Disease [J].
Vannier, Augustin G. L. ;
Przybyszewski, Eric M. ;
Shay, Jessica ;
Patel, Suraj J. ;
Schaefer, Esperance ;
Goodman, Russell P. ;
Luther, Jay .
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2023, 21 (06) :1571-1580
[26]   Global and regional burden of alcohol-associated liver disease and alcohol use disorder in the elderly [J].
Danpanichkul, Pojsakorn ;
Suparan, Kanokphong ;
Ng, Cheng Han ;
Dejvajara, Disatorn ;
Kongarin, Siwanart ;
Panpradist, Nuttada ;
Chaiyakunapruk, Nathorn ;
Muthiah, Mark D. ;
Chen, Vincent L. ;
Huang, Daniel Q. ;
Diaz, Luis Antonio ;
Noureddin, Mazen ;
Arab, Juan Pablo ;
Wijarnpreecha, Karn .
JHEP REPORTS, 2024, 6 (04)
[27]   Alcohol use disorder in alcohol-associated liver disease: Two sides of the same coin [J].
Singal, Ashwani K. ;
Leggio, Lorenzo ;
DiMartini, Andrea .
LIVER TRANSPLANTATION, 2024, 30 (02) :200-212
[28]   Liver transplantation for alcohol-associated liver disease: The changing landscape [J].
Yildiz, Eda ;
Zaffar, Duha ;
Ozturk, N. Begum ;
Gurakar, Merve ;
Donmez, A. Eylul ;
Toruner, Merih Deniz ;
Simsek, Cem ;
Gurakar, Ahmet .
HEPATOLOGY FORUM, 2025, 6 (02) :77-86
[29]   The gut microbiome in alcohol use disorder and alcohol-associated liver disease: A systematic review of clinical studies [J].
Grodin, Erica N. ;
Burnette, Elizabeth M. ;
Rodriguez, Crystal ;
Fulcher, Jennifer A. ;
Ray, Lara A. .
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH, 2024, 48 (07) :1221-1242
[30]   Gut microbiota compositional and functional fingerprint in patients with alcohol use disorder and alcohol-associated liver disease [J].
Addolorato, Giovanni ;
Ponziani, Francesca R. ;
Dionisi, Tommaso ;
Mosoni, Carolina ;
Vassallo, Gabriele A. ;
Sestito, Luisa ;
Petito, Valentina ;
Picca, Anna ;
Marzetti, Emanuele ;
Tarli, Claudia ;
Mirijello, Antonio ;
Zocco, Maria Assunta ;
Lopetuso, Loris R. ;
Antonelli, Mariangela ;
Rando, Maria M. ;
Paroni Sterbini, Francesco ;
Posteraro, Brunella ;
Sanguinetti, Maurizio ;
Gasbarrini, Antonio .
LIVER INTERNATIONAL, 2020, 40 (04) :878-888