Modifying effects of race and ethnicity and APOE on the association of physical activity with risk of Alzheimer's disease and related dementias

被引：9

作者：

Park, Song-Yi ^{[1
]}

Setiawan, Veronica Wendy ^{[2
,3
]}

White, Lon R. ^{[4
,5
]}

Wu, Anna H. ^{[2
,3
]}

Cheng, Iona ^{[6
]}

Haiman, Christopher A. ^{[2
,3
]}

Wilkens, Lynne R. ^{[1
]}

Le Marchand, Loic ^{[1
]}

Lim, Unhee ^{[1
]}

机构：

[1] Univ Hawaii, Canc Ctr, Canc Epidemiol Program, 701 Ilalo St, Honolulu, HI 96813 USA

[2] Univ Southern Calif, Keck Sch Med, Dept Populat & Publ Hlth Sci, Los Angeles, CA 90007 USA

[3] Univ Southern Calif, Norris Comprehens Canc Ctr, Los Angeles, CA 90007 USA

[4] Pacific Hlth Res & Educ Inst, Honolulu, HI USA

[5] Univ Hawaii, John Burns Sch Med, Dept Geriatr Med, Honolulu, HI 96813 USA

[6] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA USA

来源：

ALZHEIMERS & DEMENTIA | 2023年 / 19卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Alzheimer's disease; dementia; physical activity; prospective studies; race and ethnicity; sitting; MULTIETHNIC COHORT; MEDICARE CLAIMS; HEALTH; METAANALYSIS; PREVALENCE; PREVENTION; ACCURACY; CANCER; HAWAII;

D O I：

10.1002/alz.12677

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction We investigated whether the protective association of physical activity with risk of Alzheimer's disease and related dementias (ADRD) has genetic or behavioral variations. Methods In the Multiethnic Cohort, we analyzed moderate or vigorous physical activity (MVPA) reported at ages 45 to 75 among 88,047 participants in relation to 13,039 incident diagnoses of late-onset ADRD identified in Medicare claims (1999 to 2014), by five racial and ethnic groups, hours sitting, and in a subset (16%), apolipoprotein E (APOE) genotype. Results MVPA was inversely associated with ADRD (hazard ratio for >= 14 vs <2.5 hours/week: 0.83, 95% confidence interval [CI]: 0.76 to 0.90 in men; 0.88, 5% CI: 0.81 to 0.95 in women). The association was inverse in all racial and ethnic groups except Black participants (P-heterogeneity = 0.52), but stronger in individuals with lower levels of sitting duration or those who do not carry the APOE e4 risk allele. Discussion The different effects of physical activity by sitting duration and APOE genotype warrant further research.

引用

页码：507 / 517

页数：11

共 49 条

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