Synthesis of New 6-Oxo-1,6-Dihydropyrimidin-5-Carboxamides and Evaluation of Their anti-Bacterial and anti-Oxidant Activities

被引：3

作者：

Rambabu, G. ^{[1
,2
]}

Kiran, Y. B. ^{[1
]}

Sarveswari, S. ^{[2
]}

Vijayakumar, V. ^{[2
]}

机构：

[1] Sree Vidyanikethan Engn Coll, Dept Chem, Tirupati, Andhra Pradesh, India

[2] Vellore Inst Technol, Sch Adv Sci, Dept Chem, Vellore 632014, Tamil Nadu, India

来源：

POLYCYCLIC AROMATIC COMPOUNDS | 2023年 / 43卷 / 01期

关键词：

6-Oxo-1; 6-dihydropyrimidin-5-carboxamides; anti-bacterial; anti-oxidant; micro dilution method; DPPH method; POTENT; INHIBITORS; CARBOXAMIDES; DERIVATIVES; ANTAGONISTS; AMIDES; ACID;

D O I：

10.1080/10406638.2021.2019799

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new series of 6-oxo-1,6-dihydropyrimidin-5-carboxamides (4a-m) has been synthesized and reported with good yields. All these compounds were characterized using various spectral techniques such as IR, H-1 NMR, C-13 NMR, and HRMS and then subjected to in-vitro anti-oxidant and anti-bacterial activities using DPPH and microdilution methods, respectively. Among the synthesized pyrimidine-5-carboxamides, compounds 4a-b, 4j, and 4i were found to exhibit promising antibacterial activity compared to the standard drug Neomycin. Similarly, compounds 4g-i and 4l displayed excellent anti-oxidant activities against the standard drug ascorbic acid.

引用

页码：619 / 629

页数：11

共 30 条

[1] Synthesis, Antioxidant, Antituomer Activities of Some New Thiazolopyrimidines, Pyrrolothiazolopyrimidines and Triazolopyrrolothiazolopyrimidines Derivatives [J].

Abu-Hashem, Ameen Ali ;

Youssef, Mohamed M. ;

Hussein, Hoda A. R. .

JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 2011, 58 (01) :41-48

[2] Chloropyrimidines as a new class of antimicrobial agents [J].

Agarwal, N ;

Srivastava, P ;

Raghuwanshi, SK ;

Upadhyay, DN ;

Sinha, S ;

Shukla, PK ;

Ram, VJ .

BIOORGANIC & MEDICINAL CHEMISTRY, 2002, 10 (04) :869-874

[3] Antihypertensive activity of newer 1,4-dihydro-5-pyrimidine carboxamides: Synthesis and pharmacological evaluation [J].

Alam, Ozair ;

Khan, Suroor A. ;

Siddiqui, Nadeem ;

Ahsan, Waquar ;

Verma, Suraj P. ;

Gilani, Sadaf J. .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (11) :5113-5119

[4]

[Anonymous], 2012, METH DIL ANT SUSC TE

[5] Ultrasound-promoted synthesis of novel 2-chloroquinolin-4-pyrimidine carboxylate derivatives as potential antibacterial agents [J].

Balaji, G. L. ;

Rajesh, K. ;

Ali, Shabana Kouser ;

Vijayakumar, V. .

RESEARCH ON CHEMICAL INTERMEDIATES, 2013, 39 (04) :1807-1815

[6] Bicyclic pyrimidine nucleoside analogues (BCNAs) as highly selective and potent inhibitors of varicella-zoster virus replication [J].

Balzarini, J ;

McGuigan, C .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2002, 50 (01) :5-9

[7]

Bano Tabassum, 2012, Org Med Chem Lett, V2, P34, DOI 10.1186/2191-2858-2-34

[8] Acylpyruvic acids amides and hydrazides: VIII. Synthesis of pivaloylpyruvamides and their reactions with benzylamine and arylamines [J].

Berezina, ES ;

Koz'minykh, VO ;

Igidov, NM ;

Shirinkina, SS ;

Koz'minykh, EN ;

Makhmudov, RR ;

Bukanova, EV .

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2001, 37 (04) :539-546

[9] Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1 [J].

Bissinger, Elisabeth-Maria ;

Heinke, Ralf ;

Spannhoff, Astrid ;

Eberlin, Adrien ;

Metzger, Eric ;

Cura, Vincent ;

Hassenboehler, Pierre ;

Cavarelli, Jean ;

Schuele, Roland ;

Bedford, Mark T. ;

Sippl, Wolfgang ;

Jung, Manfred .

BIOORGANIC & MEDICINAL CHEMISTRY, 2011, 19 (12) :3717-3731

[10] Optimization of 2-phenyl-pyrimidine-4-carboxamides towards potent, orally bioavailable and selective P2Y12 antagonists for inhibition of platelet aggregation [J].

Caroff, Eva ;

Meyer, Emmanuel ;

Treiber, Alexander ;

Hilpert, Kurt ;

Riederer, Markus A. .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (17) :4323-4331

← 1 2 3 →