A Review of Treatment Methods Focusing on Human Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor Cell Transplantation for Chronic Spinal Cord Injury

被引：6

作者：

Shibata, Takahiro ^{[1
,2
]}

Tashiro, Syoichi ^{[3
]}

Nakamura, Masaya ^{[1
]}

Okano, Hideyuki ^{[2
]}

Nagoshi, Narihito ^{[1
]}

机构：

[1] Keio Univ, Sch Med, Dept Orthopaed Surg, 35 Shinanomachi,Shinjuku Ku, Tokyo 1608582, Japan

[2] Keio Univ, Dept Physiol, Sch Med, 35 Shinanomachi,Shinjuku Ku, Tokyo 1608582, Japan

[3] Keio Univ, Sch Med, Dept Rehabil Med, 35 Shinanomachi,Shinjuku Ku, Tokyo 1608582, Japan

来源：

MEDICINA-LITHUANIA | 2023年 / 59卷 / 07期

基金：

日本学术振兴会;

关键词：

chronic spinal cord injury; cell transplantation; rehabilitation; combination treatment; OLFACTORY ENSHEATHING CELLS; MARROW STROMAL CELLS; FUNCTIONAL RECOVERY; DELAYED TRANSPLANTATION; ANIMAL-MODELS; EXERCISE; RATS; PLASTICITY; IMPROVES; REGENERATION;

D O I：

10.3390/medicina59071235

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cell transplantation therapy using human induced pluripotent stem cell-derived neural stem/progenitor cells (hiPSC-NS/PCs) has attracted attention as a regenerative therapy for spinal cord injury (SCI), and its efficacy in treating the subacute phase of SCI has been reported in numerous studies. However, few studies have focused on treatment in the chronic phase, which accounts for many patients, suggesting that there are factors that are difficult to overcome in the treatment of chronic SCI. The search for therapeutic strategies that focus on chronic SCI is fraught with challenges, and the combination of different therapies is thought to be the key to a solution. In addition, many issues remain to be addressed, including the investigation of therapeutic approaches for more severe injury models of chronic SCI and the acquisition of practical motor function. This review summarizes the current progress in regenerative therapy for SCI and discusses the prospects for regenerative medicine, particularly in animal models of chronic SCI.

引用

页数：11

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