Endogenous glucagon-like peptide (GLP)-1 as alternative for GLP-1 receptor agonists: Could this work and how?

被引：10

作者：

Smits, Mark M. ^{[1
,2
,3
,5
]}

Holst, Jens J. ^{[1
,4
]}

机构：

[1] Univ Copenhagen, Fac Hlth & Med Sci, Dept Biomed Sci, Copenhagen, Denmark

[2] Amsterdam Cardiovasc Sci Diabet & Metab, Amsterdam, Netherlands

[3] Amsterdam UMC locat Vrije Univ, Diabet Ctr, Dept Internal Med, Amsterdam, Netherlands

[4] Univ Copenhagen, Novo Nord Fdn Ctr Basic Metab Res, Fac Hlth & Med Sci, Copenhagen, Denmark

[5] Blegdamsvej 3B, DK-2200 Copenhagen, Denmark

来源：

DIABETES-METABOLISM RESEARCH AND REVIEWS | 2023年 / 39卷 / 08期

关键词：

diabetes; glucagon-like peptide-1; gut hormone; obesity; Y GASTRIC BYPASS; TYPE-2; DIABETES-MELLITUS; FOOD-INTAKE; INSULIN-SECRETION; GLUCOSE-TOLERANCE; SLEEVE GASTRECTOMY; BARIATRIC SURGERY; INCRETIN HORMONES; ACID-SECRETION; BODY-WEIGHT;

D O I：

10.1002/dmrr.3699

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In recent years, we have witnessed the many beneficial effects of glucagon-like peptide (GLP)-1 receptor agonists, including the reduction in cardiovascular risk in patients with type 2 diabetes, and the reduction of body weight in those with obesity. Increasing evidence suggests that these agents differ considerably from endogenous GLP-1 when it comes to their routes of action, although their clinical effects appear to be the same. Given the limitations of the GLP-1 receptor agonists, could it be useful to develop agents which stimulate GLP-1 release? Here we will discuss the differences and similarities between GLP-1 receptor agonists and endogenous GLP-1, and will detail how endogenous GLP-1-when stimulated appropriately-could have clinically relevant effects.

引用

页数：17

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