Advantages and Limitations of Ultrasound as a Screening Test for Ovarian Cancer

被引：11

作者：

Koutras, Antonios ^{[1
]}

Perros, Paraskevas ^{[1
]}

Prokopakis, Ioannis ^{[1
]}

Ntounis, Thomas ^{[1
]}

Fasoulakis, Zacharias ^{[1
]}

Pittokopitou, Savia ^{[1
]}

Samara, Athina A. ^{[2
]}

Valsamaki, Asimina ^{[3
]}

Douligeris, Athanasios ^{[1
]}

Mortaki, Anastasia ^{[1
]}

Sapantzoglou, Ioakeim ^{[1
]}

Katrachouras, Alexandros ^{[4
]}

Pagkalos, Athanasios ^{[5
]}

Symeonidis, Panagiotis ^{[6
]}

Palios, Vasileios-Chrysovalantis ^{[7
]}

Psarris, Alexandros ^{[1
]}

Theodora, Marianna ^{[1
]}

Antsaklis, Panos ^{[1
]}

Makrydimas, George ^{[8
]}

Chionis, Athanasios ^{[9
]}

Daskalakis, Georgios ^{[1
]}

Kontomanolis, Emmanuel N. ^{[6
]}

机构：

[1] Natl & Kapodistrian Univ Athens, Gen Hosp Athens ALEXANDRA, Dept Obstet & Gynecol 1, Lourou & Vasilissis Sofias Ave, Athens 11528, Greece

[2] Univ Thessaly, Dept Embryol, Larisa 41110, Greece

[3] Gen Hosp Larisa, Dept Internal Med, Tsakalof 1, Larisa 41221, Greece

[4] Univ Ioannina, Univ Gen Hosp Ioannina, Dept Obstet & Gynecol, Stavros Niarchos Str, Ioannina 45500, Greece

[5] Gen Hosp Xanthi, Dept Obstet & Gynecol, Xanthi 67100, Greece

[6] Democritus Univ Thrace, Dept Obstet & Gynecol, 6th km Alexandroupolis Makris, Alexandroupolis 68100, Greece

[7] Univ Hosp Larissa, Dept Obstet & Gynecol, Larisa 41110, Greece

[8] Univ Ioannina, Dept Obstet & Gynaecol, Ioannina 45110, Greece

[9] Laiko Gen Hosp Athens, Dept Gynecol, Agiou Thoma 17, Athens 11527, Greece

来源：

DIAGNOSTICS | 2023年 / 13卷 / 12期

关键词：

ovarian cancer (OC); ultrasound; screening test; biomarkers; CA-125; PREOPERATIVE DIAGNOSIS; EXTERNAL VALIDATION; COLLABORATIVE TRIAL; MENOPAUSAL STATUS; ADNEXAL MASSES; WOMEN; RISK; MULTICENTER; EPIDEMIOLOGY; OOPHORECTOMY;

D O I：

10.3390/diagnostics13122078

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Ovarian cancer (OC) is the seventh most common malignancy diagnosed among women, the eighth leading cause of cancer mortality globally, and the most common cause of death among all gynecological cancers. Even though recent advances in technology have allowed for more accurate radiological and laboratory diagnostic tests, approximately 60% of OC cases are diagnosed at an advanced stage. Given the high mortality rate of advanced stages of OC, early diagnosis remains the main prognostic factor. Our aim is to focus on the sonographic challenges in ovarian cancer screening and to highlight the importance of sonographic evaluation, the crucial role of the operatorGREEK TONOSs experience, possible limitations in visibility, emphasizing the importance and the necessity of quality assurance protocols that health workers have to follow and finally increasing the positive predictive value. We also analyzed how ultrasound can be combined with biomarkers (ex. CA-125) so as to increase the sensitivity of early-stage OC detection or, in addition to the gold standard examination, the CT (Computed tomography) scan in OC follow-up. Improvements in the performance and consistency of ultrasound screening could reduce the need for repeated examinations and, mainly, ensure diagnostic accuracy. Finally, we refer to new very promising techniques such as liquid biopsies. Future attempts in order to improve screening should focus on the identification of features that are unique to OC and that are present in early-stage tumors.

引用

页数：15