Regiospecific Formal [3+2] Annulations of a-keto Sulfines and N-Substituted Thioureas

被引：0

作者：

Dong, Jun ^{[1
]}

Chang, Wei ^{[1
]}

Chen, Youwei ^{[1
]}

Huang, Xingcai ^{[1
]}

机构：

[1] Yancheng Teachers Univ, Sch Chem & Environm Engn, Yancheng 224007, Jiangsu, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2023年

基金：

中国国家自然科学基金;

关键词：

Regioselectivity; Sulfines; Thioureas; Annulations; 2,4-Dithiohydantoins; DERIVATIVES; COMPLEXES; ACID; THIAZOLES; HYDANTOIN; EFFICIENT; COPPER;

D O I：

暂无

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A series of 2,4-dithiohydantoins were synthesized regiospecificlly from various phenacyl sulfoxides bearing 1-methyl-1H-tetrazole and N-substituted thioureas in moderate to excellent yields. The proposed mechanism involved the generation of a-sulfines from sulfoxides through thermolytic elimination, carbonphilic attack of sulfines by substituted thioureas, and dehydration condensation. The current method provides a safe strategy for the preparation of 2,4-dithiohydantoins.

引用

页数：6

共 43 条

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