Anticancer potential of biologically synthesized silver nanoparticles using Lantana camara leaf extract

被引:36
作者
Hublikar, Leena V. [1 ,2 ,3 ]
Ganachari, Sharanabasava V. [1 ]
Patil, Veerabhadragouda B. [4 ]
Nandi, Sahana [3 ]
Honnad, Aishwarya [3 ]
机构
[1] KLE Technol Univ, Ctr Energy & Environm, Sch Adv Sci, Hubballi 580031, India
[2] NMKRV Coll Women, Dept Chem, Bangaluru 560011, India
[3] KLEs PC Jabin Sci Coll, Dept Chem, Hubballi 580031, India
[4] Univ Pardubice, Inst Energet Mat, Fac Chem Technol, Studentska 95, Pardubice 53210, Czech Republic
关键词
Green synthesis; Lantana camara; Silver nanoparticles; Antibacterial; Anticancer; GREEN SYNTHESIS; MULTIFUNCTIONAL SILVER; BIOGENIC SYNTHESIS; FRUIT EXTRACT; IN-VITRO; ANTIBACTERIAL; BIOSYNTHESIS; METAL;
D O I
10.1007/s40204-023-00219-9
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
A Lantana camara leaf (LC) extract was used as a mild reducing agent to produce silver metal nanoparticles (LC-AgNPs) efficiently. The size, shape, and morphology of synthesized silver nanoparticles were verified. LC-AgNPs were found in LC extract by XRD. The optimal concentrations of silver nitrate and LC extract necessary for the production of stable silver nanoparticles were determined. The LC-AgNPs were found spherical in form and monodispersed. Under optimal conditions, the round LC-AgNPs of 50-90 nm were utilized to cure lung cancer (A549 cell line) and breast cancer (MCF7) cell lines. Finally, the produced LC-AgNPs enhanced anti-cancer efficacy against A549 cells, with an IC50 = 49.52 g/mL. Similarly, the effect of LC-AgNPs on MCF7 cell line was assessed using an MTT test and inhibitory concentration (IC50) was determined found that 46.67 g/mL.
引用
收藏
页码:155 / 169
页数:15
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