Rituximab Monotherapy for Grade 2-3 Lymphomatoid Granulomatosis with Central Nervous System Involvement in a Patient Receiving Methotrexate for Rheumatoid Arthritis

被引：0
|
作者：
Hosoi, Hiroki [1 ]
Tanaka, Ken
Sakaki, Ayaka
Kosako, Hideki
Iwamoto, Ryuta
Matsumoto, Ai
Arakawa, Fumiko
Yamoto, Toshikazu
Murata, Shogo
Mushino, Toshiki
Murata, Shin-Ichi
Nakao, Naoyuki
Ohshima, Koichi
Sonoki, Takashi
机构：
[1] Wakayama Med Univ, Dept Hematol Oncol, Wakayama, Japan
来源：
INTERNAL MEDICINE | 2023年 / 62卷 / 13期
关键词：
lymphomatoid granulomatosis; rheumatoid arthritis; lymphoproliferative disorder; central nervous system involvement; rituximab monotherapy;
D O I：
10.2169/internalmedicine.0636-22
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Lymphomatoid granulomatosis (LYG) is a rare lymphoproliferative disorder (LPD). The optimal manage-ment strategy of methotrexate (MTX) related-LPD with central nervous system (CNS) involvement and histo-logical features of LYG remains unclear. We herein report a case of grade 2-3 LYG in a rheumatoid arthritis patient, in which an intracranial mass accompanied by hemorrhaging and pulmonary and skin lesions devel-oped. The patient received successful rituximab monotherapy. The tumor cells in the skin and brain showed monoclonal and oligoclonal proliferation, respectively. Our case suggests that rituximab monotherapy may be effective against MTX-LPD with CNS involvement, especially in cases with LYG histology.
引用
收藏
页码：1977 / 1982
页数：6
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