Monoterpene indole alkaloids from the roots of Alstonia rupestris and their anti-inflammatory activity

被引：2
作者：
Wang, Zhi-Wei
Zhang, Jin-Ping
Wei, Quan-Hao
Lu, Zhi-Yuan
Jia, Xian-Hui
Zhao, Xiao-Dong
Wang, Xiao-Jing
机构：
[1] Sch Pharm & Pharmaceut Sci, Jinan 250117, Shandong, Peoples R China
[2] Shandong First Med Univ & Shandong Acad Med Sci, Key Lab Rare & Uncommon Dis Shandong Prov, Shandong Acad Med Sci, Inst Mat Med,NHC Key Lab Biotechnol Drugs, Jinan 250117, Shandong, Peoples R China
来源：
FITOTERAPIA | 2023年 / 171卷
基金：
中国国家自然科学基金;
关键词：
Alstonia rupestris; Indole alkaloid; Anti-inflammatory activity; COX-2; TGF-beta; 1; LEAVES;
D O I：
10.1016/j.fitote.2023.105689
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Four new monoterpene indole alkaloids (1-4) together with twelve known alkaloids (5-16) were isolated from the roots of Alstonia rupestris. Compound 1 was the first example of C-2-symmetric heteroyohimbine-type indole alkaloid homodimer obtained from natural plant resource. Their structures were elucidated on the basis of spectroscopic data. The absolute configuration of 1 was determined by comparison of its calculated and experimental electronic circular dichroism (ECD) spectra. All compounds were evaluated for their anti-inflammatory activities by measuring their NO inhibitory effects in LPS-stimulated RAW 264.7 cells. Com-pound 2 showed strong NO inhibition with IC50 value of 4.2 +/- 1.3 mu M. Moreover, compound 2 could decrease the expressions of cyclooxygenase-2 (COX-2) and transforming growth factor beta-1 (TGF-beta 1).
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页数：7
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