Probiotic Consortium Confers Synergistic Anti-Inflammatory Effects in Inflammatory Disorders

被引：8

作者：

Lee, Changhon ^{[1
,5
]}

Kim, Seung Won ^{[1
]}

Verma, Ravi ^{[2
,6
]}

Noh, Jaegyun ^{[1
]}

Park, John Chulhoon ^{[1
]}

Park, Sunhee ^{[2
,7
]}

Lee, Haena ^{[1
]}

Park, Hye Eun ^{[1
]}

Kim, Chan Johng ^{[1
,8
,9
]}

Byun, Seohyun ^{[1
,10
]}

Ko, Haeun ^{[1
]}

Choi, Seungyeon ^{[2
]}

Kim, Inhae ^{[2
]}

Jeon, Soomin ^{[3
]}

Lee, Junglyoul ^{[3
]}

Im, Sin-Hyeog ^{[1
,2
,4
]}

机构：

[1] Pohang Univ Sci & Technol POSTECH, POSTECH Biotech Ctr, Dept Life Sci, Pohang 37673, South Korea

[2] ImmmunoBiome Inc, 77 Cheongam Ro, Pohang 37673, South Korea

[3] Hy Co Ltd, 22 Giheungdanji Ro,24 Beon Gil, Yongin 17086, South Korea

[4] Yonsei Univ, Inst Convergence Res & Educ, Seoul 03722, South Korea

[5] Harvard Med Sch, Blavatnik Inst, Dept Immunol, Boston, MA 02115 USA

[6] Jawaharlal Nehru Univ, Sch Biotechnol, New Delhi 110067, India

[7] Korea Inst Sci & Technol KIST, Nat Prod Informat Res Ctr, Kangnung 25451, South Korea

[8] Univ Washington, Dept Biochem, Seattle, WA 98195 USA

[9] Univ Washington, Inst Prot Design, Seattle, WA 98195 USA

[10] Celltrion Inc, 22 Acad Ro,51 Beon Gil, Incheon 22014, South Korea

来源：

NUTRIENTS | 2024年 / 16卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

probiotic consortium; microbiota; atopic dermatitis; regulatory T cell; inflammatory colitis; REGULATORY T-CELLS; DENDRITIC CELLS; GUT MICROBIOTA; IMMUNITY; DISEASE; AXIS;

D O I：

10.3390/nu16060790

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The composition and diversity of gut microbiota significantly influence the immune system and are linked to various diseases, including inflammatory and allergy disorders. While considerable research has focused on exploring single bacterial species or consortia, the optimal strategies for microbiota-based therapeutics remain underexplored. Specifically, the comparative effectiveness of bacterial consortia versus individual species warrants further investigation. In our study, we assessed the impact of the bacterial consortium MPRO, comprising Lactiplantibacillus plantarum HY7712, Bifidobacterium animalis ssp. lactis HY8002, and Lacticaseibacillus casei HY2782, in comparison to its individual components. The administration of MPRO demonstrated enhanced therapeutic efficacy in experimental models of atopic dermatitis and inflammatory colitis when compared to single strains. MPRO exhibited the ability to dampen inflammatory responses and alter the gut microbial landscape significantly. Notably, MPRO administration led to an increase in intestinal CD103+CD11b+ dendritic cells, promoting the induction of regulatory T cells and the robust suppression of inflammation in experimental disease settings. Our findings advocate the preference for bacterial consortia over single strains in the treatment of inflammatory disorders, carrying potential clinical relevance.

引用

页数：16

共 43 条

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