Construction of Polyheterocyclic Compounds by Lewis Acid Mediated Intramolecular [3+2] Cycloaddition Reaction

被引：3

作者：

Dahiya, Pooja ^{[1
]}

Yadav, Anoop ^{[1
]}

Budhwan, Rajnish ^{[1
]}

Peddinti, Rama Krishna ^{[1
]}

机构：

[1] Indian Inst Technol Roorkee, Dept Chem, Roorkee 247667, Uttarakhand, India

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 26卷 / 31期

关键词：

domino reactions; cycloadditions; heterocyclic compounds; pyrrole-fused scaffolds; synthetic methods; N BOND FORMATION; BIOLOGICAL EVALUATION; DOMINO REACTION; C-C; PYRROLE; CYCLIZATION; DERIVATIVES; FUNCTIONALIZATIONS; POLYMERIZATION; ANTICANCER;

D O I：

10.1002/ejoc.202300251

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient domino approach has been developed for the synthesis of polyheterocyclic derivatives constituting pyrrole moiety. Lewis acid catalyzed reaction of 2-substituted-2-hydroxy-indane-1,3-diones and 1,4-benzoxazinone derivatives resulted in the formation of polyheterocyclic compounds under metal-free and mild conditions in good to excellent yield. The reaction is highly regioselective for C-C and C-N bond construction proceeded via intramolecular [3+2] cycloaddition reaction. The protocol is highly efficient, obviates column chromatography and the products are obtained by simple filtration followed by washing with solvent.

引用

页数：6

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