Evaluation of renal cold ischemia-reperfusion injury with intravoxel incoherent motion diffusion-weighted imaging and blood oxygenation level-dependent MRI in a rat model
被引:5
作者:
Ren, Yan
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机构:
Tianjin First Cent Hosp, Tianjin Inst Imaging Med, Dept Radiol, Tianjin, Peoples R ChinaTianjin First Cent Hosp, Tianjin Inst Imaging Med, Dept Radiol, Tianjin, Peoples R China
Ren, Yan
[1
]
Chen, Lihua
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机构:
Tianjin First Cent Hosp, Tianjin Inst Imaging Med, Dept Radiol, Tianjin, Peoples R ChinaTianjin First Cent Hosp, Tianjin Inst Imaging Med, Dept Radiol, Tianjin, Peoples R China
Chen, Lihua
[1
]
Yuan, Yizhong
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机构:
Tianjin Med Univ, Dept Radiol, Gen Hosp, Tianjin, Peoples R ChinaTianjin First Cent Hosp, Tianjin Inst Imaging Med, Dept Radiol, Tianjin, Peoples R China
Yuan, Yizhong
[2
]
Xu, Jipan
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机构:
Tianjin Med Univ, Tianjin Inst Imaging Med, Dept Radiol, Cent Hosp 1, Tianjin, Peoples R ChinaTianjin First Cent Hosp, Tianjin Inst Imaging Med, Dept Radiol, Tianjin, Peoples R China
Xu, Jipan
[3
]
Xia, Fangjie
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机构:
Tianjin Med Univ, Tianjin Inst Imaging Med, Dept Radiol, Cent Hosp 1, Tianjin, Peoples R ChinaTianjin First Cent Hosp, Tianjin Inst Imaging Med, Dept Radiol, Tianjin, Peoples R China
Xia, Fangjie
[3
]
Zhu, Jinxia
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机构:
Siemens Healthcare Ltd, MR Collaborat, Beijing, Peoples R ChinaTianjin First Cent Hosp, Tianjin Inst Imaging Med, Dept Radiol, Tianjin, Peoples R China
Zhu, Jinxia
[4
]
Shen, Wen
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机构:
Tianjin First Cent Hosp, Tianjin Inst Imaging Med, Dept Radiol, Tianjin, Peoples R ChinaTianjin First Cent Hosp, Tianjin Inst Imaging Med, Dept Radiol, Tianjin, Peoples R China
Shen, Wen
[1
]
机构:
[1] Tianjin First Cent Hosp, Tianjin Inst Imaging Med, Dept Radiol, Tianjin, Peoples R China
[2] Tianjin Med Univ, Dept Radiol, Gen Hosp, Tianjin, Peoples R China
[3] Tianjin Med Univ, Tianjin Inst Imaging Med, Dept Radiol, Cent Hosp 1, Tianjin, Peoples R China
[4] Siemens Healthcare Ltd, MR Collaborat, Beijing, Peoples R China
Purpose: Cold ischemia-reperfusion injury (CIRI) is one of the most serious complications following renal transplantation. The current study investigated the feasibility of Intravoxel Incoherent Motion (IVIM) imaging and blood oxygenation level-dependent (BOLD) in the evaluation of different degrees of renal cold ischemia-reperfusion injury in a rat model.Methods: Seventy five rats were randomly divided into three groups (N = 25 for each group): T0: sham-operated group, T2/T4: CIRI groups with different cold ischemia hours (2, 4 h, respectively). The rat model of CIRI group was established by left kidney cold ischemia with right nephrectomy. All the rats received a baseline MRI before the surgery. Five rats in each group were randomly selected to undergo an MRI examination at 1 h, day 1, day 2 and day 5 after CIRI. The IVIM and BOLD parameters were studied in the renal cortex (CO), the outer stripe of the outer medulla (OSOM), and the inner stripe of the outer medulla (ISOM) followed by histological analysis to examine Paller scores, peritubular capillary (PTC) density, apoptosis rate and biochemical indicators to obtain the contents of serum creatinine (Scr), blood urea nitrogen (BUN), superoxide dismutase (SOD) and malondialdehyde (MDA).Results: The D, D*, PF and T2* values in the CIRI groups were lower than those in the sham-operated group at all timepoints (all p < 0.05). The prolonged cold ischemia times resulted in gradually lower D, D*, PF and T2* values (all p < 0.05). The D and T2* values of cortex and OSOM in Group T0 and T2 returned to the baseline level (all p > 0.05) except Group T4. The D* and PF values of cortex, OSOM and ISOM in Group T2 and T4 still remained below the normal levels (all p < 0.05) except Group T0. D, D*, PF and T2* values were strongly correlated with histopathological (Paller scores, PTC density and apoptosis rate) and the biochemistry indicators (SOD and MDA) (|r|>0.6, p < 0.001). D*, PF and T2* values were moderately to poorly correlated with some biochemistry indicators (Scr and BUN) (|r|<0.5, p < 0.05).Conclusion: IVIM and BOLD can serve as noninvasive radiologic markers for monitoring different degrees of renal impairment and recovery after renal CIRI.
机构:
Xuzhou Med Univ, Dept Nephrol, Affiliated Hosp, 99 West Huai Hai Rd, Xuzhou, Jiangsu, Peoples R China
Xuzhou Med Univ, Dept Internal Med & Diagnost, Xuzhou, Jiangsu, Peoples R China
Li Huili Hosp, Dept Rheumatol, Ningbo Med Treatment Ctr, Ningbo, Peoples R ChinaXuzhou Med Univ, Dept Nephrol, Affiliated Hosp, 99 West Huai Hai Rd, Xuzhou, Jiangsu, Peoples R China
Chen, Lu
Wang, Yanping
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机构:
Xuzhou Med Univ, Dept Nephrol, Affiliated Hosp, 99 West Huai Hai Rd, Xuzhou, Jiangsu, Peoples R China
Xuzhou Med Univ, Dept Internal Med & Diagnost, Xuzhou, Jiangsu, Peoples R ChinaXuzhou Med Univ, Dept Nephrol, Affiliated Hosp, 99 West Huai Hai Rd, Xuzhou, Jiangsu, Peoples R China
Wang, Yanping
Li, Shulin
论文数: 0引用数: 0
h-index: 0
机构:
Xuzhou Med Univ, Dept Nephrol, Affiliated Hosp, 99 West Huai Hai Rd, Xuzhou, Jiangsu, Peoples R China
Xuzhou Med Univ, Dept Internal Med & Diagnost, Xuzhou, Jiangsu, Peoples R ChinaXuzhou Med Univ, Dept Nephrol, Affiliated Hosp, 99 West Huai Hai Rd, Xuzhou, Jiangsu, Peoples R China
Li, Shulin
Zuo, Bangjie
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h-index: 0
机构:
Xuzhou Med Univ, Dept Nephrol, Affiliated Hosp, 99 West Huai Hai Rd, Xuzhou, Jiangsu, Peoples R China
Xuzhou Med Univ, Dept Internal Med & Diagnost, Xuzhou, Jiangsu, Peoples R ChinaXuzhou Med Univ, Dept Nephrol, Affiliated Hosp, 99 West Huai Hai Rd, Xuzhou, Jiangsu, Peoples R China
Zuo, Bangjie
Zhang, Xiangyu
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h-index: 0
机构:
Xuzhou Med Univ, Dept Nephrol, Affiliated Hosp, 99 West Huai Hai Rd, Xuzhou, Jiangsu, Peoples R China
Xuzhou Med Univ, Dept Internal Med & Diagnost, Xuzhou, Jiangsu, Peoples R ChinaXuzhou Med Univ, Dept Nephrol, Affiliated Hosp, 99 West Huai Hai Rd, Xuzhou, Jiangsu, Peoples R China
Zhang, Xiangyu
Wang, Fengzhen
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h-index: 0
机构:
Xuzhou Med Univ, Dept Pharmaceut, Affiliated Hosp, Xuzhou, Jiangsu, Peoples R ChinaXuzhou Med Univ, Dept Nephrol, Affiliated Hosp, 99 West Huai Hai Rd, Xuzhou, Jiangsu, Peoples R China
Wang, Fengzhen
Sun, Dong
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机构:
Xuzhou Med Univ, Dept Nephrol, Affiliated Hosp, 99 West Huai Hai Rd, Xuzhou, Jiangsu, Peoples R China
Xuzhou Med Univ, Dept Internal Med & Diagnost, Xuzhou, Jiangsu, Peoples R ChinaXuzhou Med Univ, Dept Nephrol, Affiliated Hosp, 99 West Huai Hai Rd, Xuzhou, Jiangsu, Peoples R China
机构:Univ Hong Kong, Lab Biomed Imaging & Signal Proc, Dept Elect & Elect Engn, Pokfulam, Hong Kong, Peoples R China
Cheung, Jerry S.
Fan, Shu Juan
论文数: 0引用数: 0
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机构:Univ Hong Kong, Lab Biomed Imaging & Signal Proc, Dept Elect & Elect Engn, Pokfulam, Hong Kong, Peoples R China
Fan, Shu Juan
Chow, April M.
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机构:Univ Hong Kong, Lab Biomed Imaging & Signal Proc, Dept Elect & Elect Engn, Pokfulam, Hong Kong, Peoples R China
Chow, April M.
Zhang, Jingbo
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机构:
Univ Hong Kong, Dept Diagnost Radiol, Pokfulam, Hong Kong, Peoples R ChinaUniv Hong Kong, Lab Biomed Imaging & Signal Proc, Dept Elect & Elect Engn, Pokfulam, Hong Kong, Peoples R China
Zhang, Jingbo
Man, Kwan
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机构:
Univ Hong Kong, Dept Surg, Pokfulam, Hong Kong, Peoples R ChinaUniv Hong Kong, Lab Biomed Imaging & Signal Proc, Dept Elect & Elect Engn, Pokfulam, Hong Kong, Peoples R China
Man, Kwan
Wu, Ed X.
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机构:
Univ Hong Kong, Lab Biomed Imaging & Signal Proc, Dept Elect & Elect Engn, Pokfulam, Hong Kong, Peoples R ChinaUniv Hong Kong, Lab Biomed Imaging & Signal Proc, Dept Elect & Elect Engn, Pokfulam, Hong Kong, Peoples R China
机构:
Xuzhou Med Univ, Dept Nephrol, Affiliated Hosp, 99 West Huai Hai Rd, Xuzhou, Jiangsu, Peoples R China
Xuzhou Med Univ, Dept Internal Med & Diagnost, Xuzhou, Jiangsu, Peoples R China
Li Huili Hosp, Dept Rheumatol, Ningbo Med Treatment Ctr, Ningbo, Peoples R ChinaXuzhou Med Univ, Dept Nephrol, Affiliated Hosp, 99 West Huai Hai Rd, Xuzhou, Jiangsu, Peoples R China
Chen, Lu
Wang, Yanping
论文数: 0引用数: 0
h-index: 0
机构:
Xuzhou Med Univ, Dept Nephrol, Affiliated Hosp, 99 West Huai Hai Rd, Xuzhou, Jiangsu, Peoples R China
Xuzhou Med Univ, Dept Internal Med & Diagnost, Xuzhou, Jiangsu, Peoples R ChinaXuzhou Med Univ, Dept Nephrol, Affiliated Hosp, 99 West Huai Hai Rd, Xuzhou, Jiangsu, Peoples R China
Wang, Yanping
Li, Shulin
论文数: 0引用数: 0
h-index: 0
机构:
Xuzhou Med Univ, Dept Nephrol, Affiliated Hosp, 99 West Huai Hai Rd, Xuzhou, Jiangsu, Peoples R China
Xuzhou Med Univ, Dept Internal Med & Diagnost, Xuzhou, Jiangsu, Peoples R ChinaXuzhou Med Univ, Dept Nephrol, Affiliated Hosp, 99 West Huai Hai Rd, Xuzhou, Jiangsu, Peoples R China
Li, Shulin
Zuo, Bangjie
论文数: 0引用数: 0
h-index: 0
机构:
Xuzhou Med Univ, Dept Nephrol, Affiliated Hosp, 99 West Huai Hai Rd, Xuzhou, Jiangsu, Peoples R China
Xuzhou Med Univ, Dept Internal Med & Diagnost, Xuzhou, Jiangsu, Peoples R ChinaXuzhou Med Univ, Dept Nephrol, Affiliated Hosp, 99 West Huai Hai Rd, Xuzhou, Jiangsu, Peoples R China
Zuo, Bangjie
Zhang, Xiangyu
论文数: 0引用数: 0
h-index: 0
机构:
Xuzhou Med Univ, Dept Nephrol, Affiliated Hosp, 99 West Huai Hai Rd, Xuzhou, Jiangsu, Peoples R China
Xuzhou Med Univ, Dept Internal Med & Diagnost, Xuzhou, Jiangsu, Peoples R ChinaXuzhou Med Univ, Dept Nephrol, Affiliated Hosp, 99 West Huai Hai Rd, Xuzhou, Jiangsu, Peoples R China
Zhang, Xiangyu
Wang, Fengzhen
论文数: 0引用数: 0
h-index: 0
机构:
Xuzhou Med Univ, Dept Pharmaceut, Affiliated Hosp, Xuzhou, Jiangsu, Peoples R ChinaXuzhou Med Univ, Dept Nephrol, Affiliated Hosp, 99 West Huai Hai Rd, Xuzhou, Jiangsu, Peoples R China
Wang, Fengzhen
Sun, Dong
论文数: 0引用数: 0
h-index: 0
机构:
Xuzhou Med Univ, Dept Nephrol, Affiliated Hosp, 99 West Huai Hai Rd, Xuzhou, Jiangsu, Peoples R China
Xuzhou Med Univ, Dept Internal Med & Diagnost, Xuzhou, Jiangsu, Peoples R ChinaXuzhou Med Univ, Dept Nephrol, Affiliated Hosp, 99 West Huai Hai Rd, Xuzhou, Jiangsu, Peoples R China
机构:Univ Hong Kong, Lab Biomed Imaging & Signal Proc, Dept Elect & Elect Engn, Pokfulam, Hong Kong, Peoples R China
Cheung, Jerry S.
Fan, Shu Juan
论文数: 0引用数: 0
h-index: 0
机构:Univ Hong Kong, Lab Biomed Imaging & Signal Proc, Dept Elect & Elect Engn, Pokfulam, Hong Kong, Peoples R China
Fan, Shu Juan
Chow, April M.
论文数: 0引用数: 0
h-index: 0
机构:Univ Hong Kong, Lab Biomed Imaging & Signal Proc, Dept Elect & Elect Engn, Pokfulam, Hong Kong, Peoples R China
Chow, April M.
Zhang, Jingbo
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hong Kong, Dept Diagnost Radiol, Pokfulam, Hong Kong, Peoples R ChinaUniv Hong Kong, Lab Biomed Imaging & Signal Proc, Dept Elect & Elect Engn, Pokfulam, Hong Kong, Peoples R China
Zhang, Jingbo
Man, Kwan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hong Kong, Dept Surg, Pokfulam, Hong Kong, Peoples R ChinaUniv Hong Kong, Lab Biomed Imaging & Signal Proc, Dept Elect & Elect Engn, Pokfulam, Hong Kong, Peoples R China
Man, Kwan
Wu, Ed X.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hong Kong, Lab Biomed Imaging & Signal Proc, Dept Elect & Elect Engn, Pokfulam, Hong Kong, Peoples R ChinaUniv Hong Kong, Lab Biomed Imaging & Signal Proc, Dept Elect & Elect Engn, Pokfulam, Hong Kong, Peoples R China