Collagens in Cancer: Structural Regulators and Guardians of Cancer Progression

被引：46

作者：

De Martino, Daniela ^{[1
]}

Bravo-Cordero, Jose Javier ^{[1
,2
]}

机构：

[1] Icahn Sch Med Mt Sinai, Tisch Canc Inst, Dept Med, Div Hematol & Oncol, New York, NY USA

[2] Icahn Sch Med, Tisch Canc Inst Mt Sinai, 1468 Madison Ave, New York, NY 10029 USA

来源：

CANCER RESEARCH | 2023年 / 83卷 / 09期

关键词：

T-CELLS; RECEPTOR; STROMA; SIGNATURE; METABOLISM; EXPRESSION; SUBSTRATE; MIGRATION; CONTACT; CLONING;

D O I：

10.1158/0008-5472.CAN-22-2034

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Collagen is one of the most abundant proteins in animals and a major component of the extracellular matrix (ECM) in tissues. Besides playing a role as a structural building block of tissues, collagens can modulate the behavior of cells, and their deregulation can promote diseases such as cancer. In tumors, collagens and many other ECM molecules are mainly produced by fibroblasts, and recent evidence points toward a role of tumor-derived collagens in tumor progression and metastasis. In this review, we focus on the newly discovered functions of collagens in cancer. Novel findings have revealed the role of collagens in tumor dormancy and immune evasion, as well as their interplay with cancer cell metabolism. Collagens could serve as prognostic markers for patients with cancer, and therapeutic strategies targeting the collagen ECM have the potential to prevent tumor progression and metastasis.

引用

页码：1386 / 1392

页数：7

共 84 条

[1] Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice [J].

Albrengues, Jean ;

Shields, Mario A. ;

Ng, David ;

Park, Chun Gwon ;

Ambrico, Alexandra ;

Poindexter, Morgan E. ;

Upadhyay, Priya ;

Uyeminami, Dale L. ;

Pommier, Arnaud ;

Kuttner, Victoria ;

Bruzas, Emilis ;

Maiorino, Laura ;

Bautista, Carmelita ;

Carmona, Ellese M. ;

Gimotty, Phyllis A. ;

Fearon, Douglas T. ;

Chang, Kenneth ;

Lyons, Scott K. ;

Pinkerton, Kent E. ;

Trotman, Lloyd C. ;

Goldberg, Michael S. ;

Yeh, Johannes T. -H. ;

Egeblad, Mikala .

SCIENCE, 2018, 361 (6409) :1353-+

[2] Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma [J].

Ambrogio, Chiara ;

Gomez-Lopez, Gonzalo ;

Falcone, Mattia ;

Vidal, August ;

Nadal, Ernest ;

Crosetto, Nicola ;

Blasco, Rafael B. ;

Fernandez-Marcos, Pablo J. ;

Sanchez-Cespedes, Montserrat ;

Ren, Xiaomei ;

Wang, Zhen ;

Ding, Ke ;

Hidalgo, Manuel ;

Serrano, Manuel ;

Villanueva, Alberto ;

Santamaria, David ;

Barbacid, Mariano .

NATURE MEDICINE, 2016, 22 (03) :270-277

[3] Collagen remodeling by phagocytosis is determined by collagen substrate topology and calcium-dependent interactions of gelsolin with nonmuscle myosin IIA in cell adhesions [J].

Arora, P. D. ;

Wang, Y. ;

Bresnick, A. ;

Dawson, J. ;

Janmey, P. A. ;

McCulloch, C. A. .

MOLECULAR BIOLOGY OF THE CELL, 2013, 24 (06) :734-747

[4] Reciprocal signalling by Notch-Collagen V-CALCR retains muscle stem cells in their niche [J].

Baghdadi, Meryem B. ;

Castel, David ;

Machado, Leo ;

Fukada, So-ichiro ;

Birk, David E. ;

Relaix, Frederic ;

Tajbakhsh, Shahragim ;

Mourikis, Philippos .

NATURE, 2018, 557 (7707) :714-+

[5] Targeting Discoidin Domain Receptors DDR1 and DDR2 overcomes matrix-mediated tumor cell adaptation and tolerance to BRAF-targeted therapy in melanoma [J].

Berestjuk, Ilona ;

Lecacheur, Margaux ;

Carminati, Alexandrine ;

Diazzi, Serena ;

Rovera, Christopher ;

Prod'homme, Virginie ;

Ohanna, Mickael ;

Popovic, Ana ;

Mallavialle, Aude ;

Larbret, Frederic ;

Pisano, Sabrina ;

Audebert, Stephane ;

Passeron, Thierry ;

Gaggioli, Cedric ;

Girard, Christophe A. ;

Deckert, Marcel ;

Tartare-Deckert, Sophie .

EMBO MOLECULAR MEDICINE, 2022, 14 (02)

[6] Cysteine-rich domain of type III collagen N-propeptide inhibits fibroblast activation by attenuating TGFI3 signaling [J].

Brisson, Becky K. ;

Stewart, Daniel C. ;

Burgwin, Chelsea ;

Chenoweth, David ;

Wells, Rebecca G. ;

Adams, Sherrill L. ;

Volk, Susan W. .

MATRIX BIOLOGY, 2022, 109 :19-33

[7] Somatic mutations in collagens are associated with a distinct tumor environment and overall survival in gastric cancer [J].

Brodsky, Alexander S. ;

Khurana, Jay ;

Guo, Kevin S. ;

Wu, Elizabeth Y. ;

Yang, Dongfang ;

Siddique, Ayesha S. ;

Wong, Ian Y. ;

Uzun, Ece D. Gamsiz ;

Resnick, Murray B. .

BMC CANCER, 2022, 22 (01)

[8] Isolation, cloning, and sequence analysis of the integrin subunit α10, a β1-associated collages binding integrin expressed on chondrocytes [J].

Camper, L ;

Hellman, U ;

Lundgren-Åkerlund, E .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (32) :20383-20389

[9] Discoidin Domain Receptor 1 Expression in Activated T Cells Is Regulated by the ERK MAP Kinase Signaling Pathway [J].

Chetoui, Nizar ;

El Azreq, Mohammed-Amine ;

Boisvert, Marc ;

Bergeron, Marie-E Ve ;

Aoudjit, Fawzi .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2011, 112 (12) :3666-3674

[10] The Extracellular Matrix Receptor Discoidin Domain Receptor 1 Regulates Collagen Transcription by Translocating to the Nucleus [J].

Chiusa, Manuel ;

Hu, Wen ;

Liao, Hong-Jun ;

Su, Yan ;

Borza, Corina M. ;

de Caestecker, Mark P. ;

Skrypnyk, Nataliya I. ;

Fogo, Agnes B. ;

Pedchenko, Vadim ;

Li, Xiyue ;

Zhang, Ming-Zhi ;

Hudson, Billy G. ;

Basak, Trayambak ;

Vanacore, Roberto M. ;

Zent, Roy ;

Pozzi, Ambra .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2019, 30 (09) :1605-1624

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