Telomerase reverse transcriptase and neurodegenerative diseases

被引：12

作者：

Yu, Xin ^{[1
]}

Liu, Meng-Meng ^{[1
]}

Zheng, Cai-Yun ^{[1
]}

Liu, Yu-Tong ^{[1
]}

Wang, Zhuo ^{[1
]}

Wang, Zhan-You ^{[1
]}

机构：

[1] China Med Univ, Key Lab Major Chron Dis Nervous Syst Liaoning Prov, Hlth Sci Inst, Shenyang, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷

基金：

中国博士后科学基金;

关键词：

telomerase reverse transcriptase; aging; neurodegenerative diseases; T cell; nervous system; REGULATORY T-CELLS; PARKINSONS-DISEASE; ALZHEIMERS-DISEASE; OXIDATIVE STRESS; CATALYTIC SUBUNIT; EXPRESSION; TERT; SENESCENCE; PROTECTS; NEURONS;

D O I：

10.3389/fimmu.2023.1165632

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neurodegenerative diseases (NDs) are chronic conditions that result in progressive damage to the nervous system, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and Amyotrophic lateral sclerosis (ALS). Age is a major risk factor for NDs. Telomere shortening is a biological marker of cellular aging, and telomerase reverse transcriptase (TERT) has been shown to slow down this process by maintaining telomere length. The blood-brain barrier (BBB) makes the brain a unique immune organ, and while the number of T cells present in the central nervous system is limited, they play an important role in NDs. Research suggests that NDs can be influenced by modulating peripheral T cell immune responses, and that TERT may play a significant role in T cell senescence and NDs. This review focuses on the current state of research on TERT in NDs and explores the potential connections between TERT, T cells, and NDs. Further studies on aging and telomeres may provide valuable insights for developing therapeutic strategies for age-related diseases.

引用

页数：8

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