Poor glycemic control in type-2 diabetic patients infected with hepatitis B: A retrospective propensity-matched study

被引:6
作者
Cai, Ting [1 ,2 ]
Yue, Tingting [1 ]
Xu, Ming [1 ]
Zhang, Pan [1 ]
Wang, Yue [1 ]
Liu, Qi [1 ]
Huang, Jie [1 ]
Shen, Ting [2 ]
Yin, Qiang [3 ]
Sheng, Zhifeng [4 ]
Xiao, Yang [4 ]
Deng, Tuo [4 ]
Zhang, Min [5 ,6 ]
De Clercq, Erik [7 ]
Zhang, Chi [2 ]
Li, Guangdi [1 ,3 ]
机构
[1] Cent South Univ, Xiangya Sch Publ Hlth, Hunan Prov Key Lab Clin Epidemiol, Changsha, Peoples R China
[2] Hunan Normal Univ, Hunan Prov Peoples Hosp, Affiliated Hosp 1, Changsha, Peoples R China
[3] Hunan Childrens Hosp, Changsha, Peoples R China
[4] Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Metab Dis, Dept Metab & Endocrinol,Key Lab Diabet Immunol,Hun, Changsha, Hunan, Peoples R China
[5] Cent South Univ, Inst Hepatol, Changsha, Hunan, Peoples R China
[6] Cent South Univ, Xiangya Hosp 2, Dept Infect Dis, Changsha, Hunan, Peoples R China
[7] Katholieke Univ Leuven, Rega Inst Med Res, Dept Microbiol Immunol & Transplantat, Leuven, Belgium
关键词
Glycemic control; HBV; Hemoglobin A1c; Propensity score matching; Type; 2; diabetes; VIRUS INFECTION; INSULIN-RESISTANCE; LIVER-DISEASE; MELLITUS; ASSOCIATION; PREVALENCE; IMPACT; COMPLICATIONS; BURDEN;
D O I
10.1002/jmv.28635
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Hepatitis B virus (HBV) infection and type-2 diabetes mellitus (T2DM) affect millions of individuals worldwide, whereas their interplay remains largely unclear. Here, we analyzed a large cohort of 330 HBV-infected inpatients with T2DM (so-called HBV + T2DM patients) and 330 T2DM inpatients without HBV infection (T2DM patients). Poor glycemic control was defined by glycated hemoglobin (HbA1c) >= 7%. Among 330 HBV + T2DM patients, 252 (76%) aged >= 50 years, 223 (68%) were males, 205 (62%) experienced poor glycemic control. The propensity-score matching approach was applied to match patient age, gender, comorbidities, and antidiabetic treatment between T2DM + HBV and T2DM patients. Compared with T2DM patients, HBV + T2DM patients had poorer glycemic control, longer hospitalization length, and higher alanine aminotransferase (p < 0.05). HBV + T2DM patients with HBV DNA >= 100 IU/mL or HBsAg >= 0.05 IU/mL had worse HbA1c control than T2DM patients without HBV infection (p < 0.05). HBV + T2DM patients who received no anti-HBV therapy had worse HbA1c control than HBV + T2DM patients receiving anti-HBV therapy (p < 0.05). Both insulin and anti-HBV therapy were significant factors associated with glycemic control in HBV + T2DM patients. Overall, HBV + T2DM patients exhibited poorer glycemic control than T2DM patients, but their clinical outcomes were likely improved by insulin plus anti-HBV treatment. Early management of HBV infection likely contributes to better clinical outcomes in HBV-infected patients with T2DM.
引用
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页数:15
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