Impact and cost-effectiveness of the national scale-up of HIV pre-exposure prophylaxis among female sex workers in South Africa: a modelling analysis

被引：3

作者：

Stone, Jack ^{[1
,3
]}

Bothma, Rutendo ^{[4
]}

Gomez, Gabriela B. ^{[2
,5
]}

Eakle, Robyn ^{[4
,5
,6
]}

Mukandavire, Christinah ^{[3
,7
]}

Subedar, Hasina ^{[8
]}

Fraser, Hannah ^{[3
]}

Boily, Marie-Claude ^{[7
]}

Schwartz, Sheree ^{[9
]}

Coetzee, Jenny ^{[10
,11
,12
]}

Otwombe, Kennedy ^{[10
,13
]}

Milovanovic, Minja ^{[10
,12
]}

Baral, Stefan ^{[9
]}

Johnson, Leigh F.

Venter, Willem Daniel Francois

Rees, Helen ^{[4
]}

Vickerman, Peter ^{[3
]}

机构：

[1] Univ Bristol, Bristol Med Sch, Bristol BS8 2BN, England

[2] Sanofi Pasteur, Lyon, France

[3] Univ Bristol, Populat Hlth Sci, Bristol, England

[4] Univ Witwatersrand, Wits RHI, Johannesburg, South Africa

[5] London Sch Hyg & Trop Med, Dept Global Hlth & Dev, London, England

[6] US Agcy Int Dev USAID, Off HIV AIDS, Washington, DC USA

[7] Imperial Coll London, Dept Infect Dis Epidemiol, London, England

[8] Natl Dept Hlth, Pretoria, South Africa

[9] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[10] Univ Witwatersrand, Fac Hlth Sci, Perinatal HIV Res Unit, Johannesburg, South Africa

[11] South African Med Res Council, Fac Hlth Sci, Ezintsha, Cape Town, South Africa

[12] African Potential Management Consultancy, Kyalami, South Africa

[13] Univ Witwatersrand, Fac Hlth Sci, Sch Publ Hlth, Johannesburg, South Africa

来源：

JOURNAL OF THE INTERNATIONAL AIDS SOCIETY | 2023年 / 26卷 / 02期

基金：

英国惠康基金; 美国国家卫生研究院; 英国医学研究理事会;

关键词：

female sex workers; HIV; mathematical modelling; pre-exposure prophylaxis; prevention; South Africa; SUB-SAHARAN AFRICA; PREVENTION; INFECTION; RISK; SELECTION; TIME;

D O I：

10.1002/jia2.26063

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IntroductionIn 2016, South Africa (SA) initiated a national programme to scale-up pre-exposure prophylaxis (PrEP) among female sex workers (FSWs), with similar to 20,000 PrEP initiations among FSWs (similar to 14% of FSW) by 2020. We evaluated the impact and cost-effectiveness of this programme, including future scale-up scenarios and the potential detrimental impact of the COVID-19 pandemic. MethodsA compartmental HIV transmission model for SA was adapted to include PrEP. Using estimates on self-reported PrEP adherence from a national study of FSW (67.7%) and the Treatment and Prevention for FSWs (TAPS) PrEP demonstration study in SA (80.8%), we down-adjusted TAPS estimates for the proportion of FSWs with detectable drug levels (adjusted range: 38.0-70.4%). The model stratified FSW by low (undetectable drug; 0% efficacy) and high adherence (detectable drug; 79.9%; 95% CI: 67.2-87.6% efficacy). FSWs can transition between adherence levels, with lower loss-to-follow-up among highly adherent FSWs (aHR: 0.58; 95% CI: 0.40-0.85; TAPS data). The model was calibrated to monthly data on the national scale-up of PrEP among FSWs over 2016-2020, including reductions in PrEP initiations during 2020. The model projected the impact of the current programme (2016-2020) and the future impact (2021-2040) at current coverage or if initiation and/or retention are doubled. Using published cost data, we assessed the cost-effectiveness (healthcare provider perspective; 3% discount rate; time horizon 2016-2040) of the current PrEP provision. ResultsCalibrated to national data, model projections suggest that 2.1% of HIV-negative FSWs were currently on PrEP in 2020, with PrEP preventing 0.45% (95% credibility interval, 0.35-0.57%) of HIV infections among FSWs over 2016-2020 or 605 (444-840) infections overall. Reductions in PrEP initiations in 2020 possibly reduced infections averted by 18.57% (13.99-23.29). PrEP is cost-saving, with $1.42 (1.03-1.99) of ART costs saved per dollar spent on PrEP. Going forward, existing coverage of PrEP will avert 5,635 (3,572-9,036) infections by 2040. However, if PrEP initiation and retention doubles, then PrEP coverage increases to 9.9% (8.7-11.6%) and impact increases 4.3 times with 24,114 (15,308-38,107) infections averted by 2040. ConclusionsOur findings advocate for the expansion of PrEP to FSWs throughout SA to maximize its impact. This should include strategies to optimize retention and should target women in contact with FSW services.

引用

页数：12

共 67 条

[1] A Review of Pre-Exposure Prophylaxis Adherence among Female Sex Workers [J].

Abou Ghayda, Ramy ;

Hong, Sung Hwi ;

Yang, Jae Won ;

Jeong, Gwang Hun ;

Lee, Keum Hwa ;

Kronbichler, Andreas ;

Solmi, Marco ;

Stubbs, Brendon ;

Koyanagi, Ai ;

Jacob, Louis ;

Oh, Hans ;

Kim, Jong Yeob ;

Shin, Jae Il ;

Smith, Lee .

YONSEI MEDICAL JOURNAL, 2020, 61 (05) :349-358

[2]

[Anonymous], 2014, South African National HIV Prevalence, Incidence and Behaviour Survey, 2012

[3]

[Anonymous], Medecins sans Frontieres (Doctors without Borders) 'South Sudan conflict: violence against healthcare'

[4]

[Anonymous], 2013, Estimating the Size of the Sex Worker Population in South Africa, P4

[5] Antiretroviral Prophylaxis for HIV Prevention in Heterosexual Men and Women [J].

Baeten, J. M. ;

Donnell, D. ;

Ndase, P. ;

Mugo, N. R. ;

Campbell, J. D. ;

Wangisi, J. ;

Tappero, J. W. ;

Bukusi, E. A. ;

Cohen, C. R. ;

Katabira, E. ;

Ronald, A. ;

Tumwesigye, E. ;

Were, E. ;

Fife, K. H. ;

Kiarie, J. ;

Farquhar, C. ;

John-Stewart, G. ;

Kakia, A. ;

Odoyo, J. ;

Mucunguzi, A. ;

Nakku-Joloba, E. ;

Twesigye, R. ;

Ngure, K. ;

Apaka, C. ;

Tamooh, H. ;

Gabona, F. ;

Mujugira, A. ;

Panteleeff, D. ;

Thomas, K. K. ;

Kidoguchi, L. ;

Krows, M. ;

Revall, J. ;

Morrison, S. ;

Haugen, H. ;

Emmanuel-Ogier, M. ;

Ondrejcek, L. ;

Coombs, R. W. ;

Frenkel, L. ;

Hendrix, C. ;

Bumpus, N. N. ;

Bangsberg, D. ;

Haberer, J. E. ;

Stevens, W. S. ;

Lingappa, J. R. ;

Celum, C. .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 367 (05) :399-410

[6] Combination HIV prevention for female sex workers: what is the evidence? [J].

Bekker, Linda-Gail ;

Johnson, Leigh ;

Cowan, Frances ;

Overs, Cheryl ;

Besada, Donela ;

Hillier, Sharon ;

Cates, Willard, Jr. .

LANCET, 2015, 385 (9962) :72-87

[7]

Bill and Melinda Gates Foundation. Methods for Economic Evaluation Project (MEEP), 2014, The Gates Reference Case: What it is, why it's important, and how to use it

[8] HIV pre-exposure prophylaxis for female sex workers: ensuring women's family planning needs are not left behind [J].