Drug-loaded balloon with built-in NIR controlled tip-separable microneedles for long-effective arteriosclerosis treatment

被引：21

作者：

Huang, Li ^{[1
,2
]}

Fang, Huaqiang ^{[1
]}

Zhang, Teng ^{[1
]}

Hu, Binbin ^{[2
]}

Liu, Shichen ^{[1
]}

Lv, Fanzhen ^{[1
]}

Zeng, Zhaoxia ^{[3
]}

Liu, Huijie ^{[2
]}

Zhou, Weimin ^{[1
]}

Wang, Xiaolei ^{[2
,4
]}

机构：

[1] Nanchang Univ, Affiliated Hosp 2, Dept Vasc Surg, Nanchang 330006, Jiangxi, Peoples R China

[2] Nanchang Univ, Inst Translat Med, Natl Engn Res Ctr Bioengn Drugs & Technol, Nanchang 330088, Jiangxi, Peoples R China

[3] Nanchang Univ, Affiliated Hosp 2, Dept Radiol, Nanchang 330006, Jiangxi, Peoples R China

[4] Nanchang Univ, Sch Chem & Chem Engn, Nanchang 330088, Jiangxi, Peoples R China

来源：

BIOACTIVE MATERIALS | 2023年 / 23卷

基金：

中国国家自然科学基金;

关键词：

Photothermal responsive; Drug delivery; Microneedles; Atherosclerosis; Drug-eluting balloon; COATED BALLOON; ELUTING STENT; PACLITAXEL; DELIVERY; ANGIOPLASTY; RESTENOSIS; TECHNOLOGY; COATINGS; PATCH;

D O I：

10.1016/j.bioactmat.2022.11.015

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Drug-eluting balloon (DEB) angioplasty has emerged as an effective treatment for cardiovascular and cerebro-vascular diseases. However, distal embolism and late lumen restenosis could be caused by drug loss during DEB handling and rapid drug metabolization. Here, a drug-loaded balloon equipped with tip-separable microneedles on the balloon surface (MNDLB) was developed. Inbuilt near-infrared (NIR) ring laser inside the catheter inner shaft was introduced to activate the biodegradable microneedle tips for the first time. The drug-loaded tips thus could be embedded in the vasculature and then released antiproliferative drug - paclitaxel slowly via polymer degradation for more than half a year. A significant increase in drug delivery efficiency and superior therapeutic effectiveness compared with the standard DEB were demonstrated using an atherosclerosis rabbit model.

引用

页码：526 / 538

页数：13

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