Molecular Epidemiology of Foot-and-Mouth Disease Viruses in the Emirate of Abu Dhabi, United Arab Emirates

被引：6

作者：

Eltahir, Yassir M. ^{[1
]}

Ishag, Hassan Zackaria Ali ^{[2
]}

Wadsworth, Jemma ^{[3
]}

Hicks, Hayley M. ^{[3
]}

Knowles, Nick J. ^{[3
]}

Mioulet, Valerie ^{[3
]}

King, Donald P. ^{[3
]}

Mohamed, Meera Saeed ^{[1
]}

Bensalah, Oum Keltoum ^{[1
]}

Yusof, Mohd Farouk ^{[2
]}

Gasim, Esmat Faisal Malik ^{[2
]}

Al Hammadi, Zulaikha Mohamed ^{[2
]}

Shah, Asma Abdi Mohamed ^{[2
]}

Abdelmagid, Yasir Ali ^{[1
]}

El Gahlan, Moustafa Abdel Meguid ^{[1
]}

Kassim, Mohanned Fawzi ^{[1
]}

Kayaf, Kaltham ^{[4
]}

Zahran, Ahmed ^{[4
]}

Al Nuaimat, Mervat Mari ^{[4
]}

机构：

[1] Anim Extens & Hlth Serv Div, Abu Dhabi Agr & Food Safety Author ADAFSA, POB 52150, Abu Dhabi, U Arab Emirates

[2] Biosecur Affairs Div, Dev & Innovat Sect, Abu Dhabi Agr & Food Safety Author ADAFSA, POB 52150, Abu Dhabi, U Arab Emirates

[3] Pirbright Inst, FAO World Reference Lab FMD WRLFMD, Pirbright GU24, England

[4] Minist Climate Change & Environm, Anim Dev & Hlth Dept, POB 1509, Dubai, U Arab Emirates

来源：

VETERINARY SCIENCES | 2024年 / 11卷 / 01期

关键词：

foot-and-mouth disease virus; United Arab Emirates; epidemiology; VP1; sequencing; phylogenetic; prototype; MIDDLE-EAST; TRANSMISSION; VACCINES; PROTOCOL; SPREAD;

D O I：

10.3390/vetsci11010032

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Foot-and-mouth disease (FMD) is endemic in the United Arab Emirates (UAE); however, FMD virus (FMDV) genotyping in small ruminants or cattle has never been reported. This study focused on FMD outbreaks that occurred during 2021 in two different regions in the Emirate of Abu Dhabi, where cases affected sheep, goats, cattle, and Arabian oryx. VP1 sequences from different isolates were characterised, and phylogenetic analysis revealed epidemiological connections between FMDV sequences collected in the UAE and neighbouring countries, which highlights the importance of implementing measures such as vaccination, animal movement controls, and biosecurity to limit the spread of the disease. Foot-and-mouth disease (FMD) is an endemic disease in the United Arab Emirates (UAE) in both wild and domestic animals. Despite this, no systematic FMD outbreak investigation accompanied by molecular characterisation of FMD viruses (FMDVs) in small ruminants or cattle has been performed, and only a single report that describes sequences for FMDVs in wildlife from the Emirate has been published. In this study, FMD outbreaks that occurred in 2021 in five animal farms and one animal market in the Emirate of Abu Dhabi were investigated. Cases involved sheep, goats, and cattle, as well as Arabian oryx (Oryx leucoryx). Twelve samples were positive for FMDV via RT-qPCR, and four samples (Arabian oryx n = 1, goat n = 2, and sheep n = 1) were successfully genotyped using VP1 nucleotide sequencing. These sequences shared 88 similar to 98% identity and were classified within the serotype O, Middle East-South Asia topotype (O/ME-SA). Phylogenetic analysis revealed that the Arabian oryx isolate (UAE/2/2021) belonged to the PanAsia-2 lineage, the ANT-10 sublineage, and was closely related to the FMDVs recently detected in neighbouring countries. The FMDV isolates from goats (UAE/10/2021 and UAE/11/2021) and from sheep (UAE/14/2021) formed a monophyletic cluster within the SA-2018 lineage that contained viruses from Bangladesh, India, and Sri Lanka. This is the first study describing the circulation of the FMDV O/ME-SA/SA-2018 sublineage in the UAE. These data shed light on the epidemiology of FMD in the UAE and motivate further systematic epidemiological studies and genomic sequencing to enhance the ongoing national animal health FMD control plan.

引用

页数：13

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