Inhibition of Factor XI: A New Era in the Treatment of Venous Thromboembolism in Cancer Patients?

被引：8

作者：

Poenou, Geraldine ^{[1
,2
]}

Heestermans, Marco ^{[2
,3
]}

Lafaie, Ludovic ^{[2
,4
]}

Accassat, Sandrine ^{[1
,5
]}

Moulin, Nathalie ^{[1
]}

Rodiere, Alexandre ^{[1
]}

Petit, Bastien ^{[1
]}

Duvillard, Cecile ^{[1
]}

Mismetti, Patrick ^{[1
,2
,5
,6
]}

Bertoletti, Laurent ^{[1
,2
,5
,6
]}

机构：

[1] St Etienne Univ Hosp Ctr, Therapeut & Vasc Medecine Dept, F-42270 St Priest En Jarez, France

[2] Jean Monnet Univ, INSERM, SAINBIOSE U 1059, F-42023 St Priest En Jarez, France

[3] French Blood Establishement Auvergne Rhone Alpes, Res Dept, F-42023 St Etienne, France

[4] St Etienne Univ Hosp Ctr, Geriatry Dept, F-42000 St Etienne, France

[5] St Etienne Univ Hosp Ctr, INSERM, Inserm U879, CIC 1408, F-42055 St Priest En Jarez, France

[6] F CRIN INNOVTE Network, F-42000 St Etienne, France

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 19期

关键词：

FXI inhibitors; cancer-associated thrombosis; venous thromboembolism; catheter-related thrombosis; MOLECULAR-WEIGHT HEPARIN; PULMONARY-EMBOLISM; THROMBUS FORMATION; TISSUE FACTOR; HIGH-RISK; PREVENTION; COAGULATION; RIVAROXABAN; ACTIVATION; DISCOVERY;

D O I：

10.3390/ijms241914433

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Direct oral anticoagulants against activated factor X and thrombin were the last milestone in thrombosis treatment. Step by step, they replaced antivitamin K and heparins in most of their therapeutic indications. As effective as the previous anticoagulant, the decreased but persistent risk of bleeding while using direct oral anticoagulants has created space for new therapeutics aiming to provide the same efficacy with better safety. On this basis, drug targeting factor XI emerged as an option. In particular, cancer patients might be one of the populations that will most benefit from this technical advance. In this review, after a brief presentation of the different factor IX inhibitors, we explore the potential benefit of this new treatment for cancer patients.

引用

页数：16

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