Pentagalloyl Glucose: A Review of Anticancer Properties, Molecular Targets, Mechanisms of Action, Pharmacokinetics, and Safety Profile

被引:17
作者
Wen, Chengli [1 ,2 ,3 ]
Dechsupa, Nathupakorn [2 ]
Yu, Zehui [4 ]
Zhang, Xu [3 ,5 ]
Liang, Sicheng [3 ,5 ]
Lei, Xianying [1 ]
Xu, Tao [1 ]
Gao, Xiaolan [1 ]
Hu, Qinxue [1 ]
Innuan, Phattarawadee [2 ]
Kantapan, Jiraporn [2 ]
Lu, Muhan [3 ,5 ]
机构
[1] Southwest Med Univ, Affiliated Hosp, Dept Intens Care Med, Luzhou 646000, Peoples R China
[2] Chiang Mai Univ, Fac Associated Med Sci, Dept Radiol Technol, Mol Imaging & Therapy Res Unit, Chiang Mai 50200, Thailand
[3] Luzhou Key Lab Human Microecol & Precis Diag & Tre, Luzhou 646000, Peoples R China
[4] Southwest Med Univ, Lab Anim Ctr, Luzhou 646000, Peoples R China
[5] Southwest Med Univ, Affiliated Hosp, Dept Gastroenterol, Luzhou 646000, Peoples R China
来源
MOLECULES | 2023年 / 28卷 / 12期
关键词
pentagalloyl glucose; gallotannin; anticancer; molecular targets; mechanisms; pharmacokinetics; safety profile; BETA-D-GLUCOSE; IN-VITRO; CANCER-CELLS; DOWN-REGULATION; LIQUID-CHROMATOGRAPHY; HEME OXYGENASE-1; PHASE ARREST; TUMOR-GROWTH; TANNIC-ACID; CYCLIN D1;
D O I
10.3390/molecules28124856
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Pentagalloyl glucose (PGG) is a natural hydrolyzable gallotannin abundant in various plants and herbs. It has a broad range of biological activities, specifically anticancer activities, and numerous molecular targets. Despite multiple studies available on the pharmacological action of PGG, the molecular mechanisms underlying the anticancer effects of PGG are unclear. Here, we have critically reviewed the natural sources of PGG, its anticancer properties, and underlying mechanisms of action. We found that multiple natural sources of PGG are available, and the existing production technology is sufficient to produce large quantities of the required product. Three plants (or their parts) with maximum PGG content were Rhus chinensis Mill, Bouea macrophylla seed, and Mangifera indica kernel. PGG acts on multiple molecular targets and signaling pathways associated with the hallmarks of cancer to inhibit growth, angiogenesis, and metastasis of several cancers. Moreover, PGG can enhance the efficacy of chemotherapy and radiotherapy by modulating various cancer-associated pathways. Therefore, PGG can be used for treating different human cancers; nevertheless, the data on the pharmacokinetics and safety profile of PGG are limited, and further studies are essential to define the clinical use of PGG in cancer therapies.
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页数:25
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