Developmental and mitochondrial toxicity assessment of perfluoroheptanoic acid (PFHpA) in zebrafish (Danio rerio)

被引：6

作者：

Huang, Michelle ^{[1
]}

Ivantsova, Emma ^{[1
]}

Konig, Isaac ^{[1
,2
]}

Patel, Neep ^{[1
]}

English, Cole ^{[1
]}

Souders II, Christopher L. ^{[1
]}

Martyniuk, Christopher J. ^{[1
,3
]}

机构：

[1] Univ Florida, Coll Vet Med, Ctr Environm & Human Toxicol, Dept Physiol Sci, Gainesville, FL 32611 USA

[2] Fed Univ Lavras UFLA, Dept Chem, Lavras, MG, Brazil

[3] UF Genet Inst, Interdisciplinary Program Biomed Sci Neurosci, Gainesville, FL USA

来源：

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2023年 / 97卷

关键词：

PERFLUORINATED COMPOUNDS; PERFLUOROOCTANOIC ACID; WATER; PERFLUOROALKYL; BEHAVIOR; CHEMICALS; SEDIMENT; EXPOSURE; SYSTEM; PFOA;

D O I：

10.1016/j.etap.2022.104037

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The potential toxicity of several perfluoroalkyl and polyfluoroalkyl substances (PFASs) to aquatic species are not well understood. Here, we assessed the sub-lethal toxicity potential of perfluoroheptanoic acid (PFHpA) to developing zebrafish. PFHpA was not acutely toxic to fish up to 50 mu M and there was > 96% survival in all treatments. Exposure to 200 mu M PFHpA decreased ATP-linked respiration of embryos. There was no evidence for ROS induction in 7-day-old larvae fish exposed to 0.1 mu M or 1 mu M PFHpA. Twenty-four transcripts related to mitochondrial complexes I through V were measured and atp06, cox4i1, and cyc1 levels were decreased in larval zebrafish in a concentration-dependent manner by PFHpA exposure. Locomotor activity was reduced in fish exposed to 0.1 mu M PFHpA based on a visual motor response test. Anxiolytic-type behaviors were not affected by PFHpA. This study contributes to environmental risk assessments for perfluorinated chemicals.

引用

页数：11

共 44 条

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